Reproducible access to tunable morphologies via the self-assembly of an amphiphilic diblock copolymer in water

Nghia P Truong; John F Quinn; Marion V Dussert; Nikolle B T de Sousa; Michael R Whittaker; Thomas P Davis

doi:10.1021/acsmacrolett.5b00111

Reproducible access to tunable morphologies via the self-assembly of an amphiphilic diblock copolymer in water

Nghia P Truong, John F Quinn, Marion V Dussert, Nikolle B T de Sousa, Michael R Whittaker, Thomas P Davis

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Article › Research › peer-review

45 Citations (Scopus)

Abstract

We report on the preparation of positively charged crew-cut nanoaggregates in water with various nonspherical (i.e., worm, flower, and large compound) and spherical (i.e., vesicle and sphere) morphologies by the self-assembly of a single diblock copolymer in water. Our facile procedure for preparing positively charged nanoparticles, when combined with the techniques for obtaining negatively charged and neutral nanoaggregates already established by Eisenberg et al., provides a versatile toolbox for the reproducible production of uniformly nanostructured particles with control over both morphology and surface chemistry. Such nanoparticles offer opportunities for the fundamental study of nanobio interactions and may open the door to novel drug and gene delivery applications.

Original language	English
Pages (from-to)	381-386
Number of pages	6
Journal	ACS Macro Letters
Volume	4
Issue number	4
DOIs	https://doi.org/10.1021/acsmacrolett.5b00111
Publication status	Published - 2015

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10.1021/acsmacrolett.5b00111

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title = "Reproducible access to tunable morphologies via the self-assembly of an amphiphilic diblock copolymer in water",

abstract = "We report on the preparation of positively charged crew-cut nanoaggregates in water with various nonspherical (i.e., worm, flower, and large compound) and spherical (i.e., vesicle and sphere) morphologies by the self-assembly of a single diblock copolymer in water. Our facile procedure for preparing positively charged nanoparticles, when combined with the techniques for obtaining negatively charged and neutral nanoaggregates already established by Eisenberg et al., provides a versatile toolbox for the reproducible production of uniformly nanostructured particles with control over both morphology and surface chemistry. Such nanoparticles offer opportunities for the fundamental study of nanobio interactions and may open the door to novel drug and gene delivery applications.",

author = "Truong, {Nghia P} and Quinn, {John F} and Dussert, {Marion V} and {de Sousa}, {Nikolle B T} and Whittaker, {Michael R} and Davis, {Thomas P}",

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AU - Truong, Nghia P

AU - Quinn, John F

AU - Dussert, Marion V

AU - de Sousa, Nikolle B T

AU - Whittaker, Michael R

AU - Davis, Thomas P

PY - 2015

Y1 - 2015

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AB - We report on the preparation of positively charged crew-cut nanoaggregates in water with various nonspherical (i.e., worm, flower, and large compound) and spherical (i.e., vesicle and sphere) morphologies by the self-assembly of a single diblock copolymer in water. Our facile procedure for preparing positively charged nanoparticles, when combined with the techniques for obtaining negatively charged and neutral nanoaggregates already established by Eisenberg et al., provides a versatile toolbox for the reproducible production of uniformly nanostructured particles with control over both morphology and surface chemistry. Such nanoparticles offer opportunities for the fundamental study of nanobio interactions and may open the door to novel drug and gene delivery applications.

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EP - 386

JO - ACS Macro Letters

JF - ACS Macro Letters

IS - 4

ER -

Reproducible access to tunable morphologies via the self-assembly of an amphiphilic diblock copolymer in water

Abstract

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Macromolecular design for bio-imaging and targeted delivery

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

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Reproducible access to tunable morphologies via the self-assembly of an amphiphilic diblock copolymer in water

Abstract

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Macromolecular design for bio-imaging and targeted delivery

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Cite this