Abstract
In a letter regarding our recent meta-analysis (Dobler et al., 2018) showing pervasive health effects of mitochondrial replacement (MR), Eyre-Walker (2018) suggested that our treatment of non-independence of data results in our analysis being obsolete. Below we explain why we consider this statement is incorrect.
The letter stated that the majority of the data points in our study originated from the same set of beetle or mouse strains, and effect size estimates are, therefore, inflated. We disagree; only three pairs of studies used the same strains—but these investigated different traits.
The letter stated that the majority of the data points in our study originated from the same set of beetle or mouse strains, and effect size estimates are, therefore, inflated. We disagree; only three pairs of studies used the same strains—but these investigated different traits.
| Original language | English |
|---|---|
| Pages (from-to) | 392-394 |
| Number of pages | 3 |
| Journal | Human Reproduction Update |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 May 2019 |
