Replication of the Frank-Starling response in a mock circulation loop

Shaun D. Gregory, Michael Stevens, Daniel Timms, Mark Pearcy

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

43 Citations (Scopus)

Abstract

Mock circulation loops (MCLs) are used to evaluate cardiovascular devices prior to in-vivo trials; however they lack the vital autoregulatory responses that occur in humans. This study aimed to develop and implement a left and right ventricular Frank-Starling response in a MCL. A proportional controller based on ventricular end diastolic volume was used to control the driving pressure of the MCL's pneumatically operated ventricles. Ventricular pressure-volume loops and end systolic pressure-volume relationships were produced for a variety of healthy and pathological conditions and compared with human data to validate the simulated Frank-Starling response. The non-linear Frank-Starling response produced in this study successfully altered left and right ventricular contractility with changing preload and was validated with previously reported data. This improvement to an already detailed MCL has resulted in a test rig capable of further refining cardiovascular devices and reducing the number of in-vivo trials.

Original languageEnglish
Title of host publication33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages6825-6828
Number of pages4
DOIs
Publication statusPublished - 26 Dec 2011
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2011 - Boston, United States of America
Duration: 30 Aug 20113 Sep 2011
Conference number: 33rd
https://ieeexplore.ieee.org/xpl/conhome/6067544/proceeding (Proceedings)

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2011
Abbreviated titleEMBC 2011
CountryUnited States of America
CityBoston
Period30/08/113/09/11
Internet address

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