Reperfusion after 4.5 hours reduces infarct growth and improves clinical outcomes

Miguel R Picanco, Soren Christensen, Bruce Charles Vivian Campbell, Leonid Churilov, Mark W Parsons, Patricia M Desmond, Peter Alan Barber, Christopher Royce Levi, Christopher F Bladin, Geoffrey Donnan, Stephen M Davis

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14 Citations (Scopus)


The currently proven time window for thrombolysis in ischemic stroke is 4?5h. Beyond this, the risks and benefits of thrombolysis are uncertain. Aims: To determine whether thrombolysis and reperfusion were beneficial after 4?5h, we examined clinical and radiological outcomes in patients treated with tissue plasminogen activator or placebo within 4?5-6h, using data from the Echoplanar Imaging Thrombolytic Evaluation Trial.
Original languageEnglish
Pages (from-to)266 - 269
Number of pages4
JournalInternational Journal of Stroke
Issue number3
Publication statusPublished - 2014

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