Renovascular hypertension: structural changes in the renal vasculature

Warwick P Anderson, Michelle M Kett, Kathleen M Stevenson, Amanda J Edgley, Kate M Denton, Sharyn M Fitzgerald

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

42 Citations (Scopus)


Experimental narrowing of the main renal artery to produce hypertension increases the aorta-glomerular capillary pressure difference and vascular resistance. This article examines the hypothesis that hypertension also may be caused by structural changes that narrow intrarenal blood vessels, similarly increasing preglomerular vascular resistance and the aortic-glomerular capillary pressure gradient. There is evidence of both wall hypertrophy and lumen narrowing of the preglomerular arteries in spontaneously hypertensive rats, with increased preglomerular resistance and aortic-glomerular capillary pressure difference. We have also attempted to induce structural changes in renal-preglomerular vessels experimentally by infusing angiotensin II at low doses (0.5 to 4.5 ng/kg per minute) into the renal artery of Sprague-Dawley rats and greyhound dogs for up to 4 weeks. This angiotensin II infusion produced apparent dose-related effects on preglomerular vessel structure and hypertension. The possibility that hypertension may be induced by structural changes in preglomerular resistance vessel walls, by simulation of the hemodynamic effects of main renal artery stenosis, deserves further investigation.
Original languageEnglish
Title of host publicationColin Johnston - A Celebration
PublisherAmerican Heart Foundation
Number of pages5
Publication statusPublished - 2000
EventColin Johnston: A celebration - Lorne, Victoria:,
Duration: 1 Jan 2000 → …


ConferenceColin Johnston: A celebration
Period1/01/00 → …

Cite this