Renal sympathetic denervation in the management of treatment-resistant hypertension

Henry Krum

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


The contribution of sympathetic activation to the genesis and progression of hypertension has been well recognised for decades [1]. A step-up has been demonstrated in muscle sympathetic nerve activity from normal to high-normal blood pressure, white coat to borderline to established hypertension, with or without left ventricular hypertrophy [2]. These data are supported by other measures of sympathetic activation in man, specifically spillover of noradrenaline into plasma. A significant increase was noted in essential hypertension patients in comparison to normotensive controls [3] in a study of renal spillover. This increase was particularly prominent in younger hypertensives, aged 20-39 years
Original languageEnglish
Title of host publicationCardio-Renal Clinical Challenges
EditorsDavid Goldsmith, Adrian Covic, Jonas Spaak
Place of PublicationCham Switzerland
Number of pages6
ISBN (Print)978-3-319-09161-7
Publication statusPublished - 2015

Cite this