Abstract
Objective: To determine the incidence of acute kidney injury (AKI) in aged patients receiving empiric gentamicin therapy. Methods: Patients aged ≥65 years receiving gentamicin upon admission between 2013 and 2015 at two Australian hospitals were retrospectively studied. AKI was defined as a rise in creatinine by ≥50% and/or ≥26.5 μmol/L. Results: Most patients (95%) received a single dose of gentamicin. The incidence of AKI was 15% (36/242 patients). A composite outcome of persistent kidney injury, requirement for renal replacement therapy or inpatient death in a patient with AKI occurred in 10 (4%) patients. Patients who developed AKI were older (median 80.5 vs 78 years, P = 0.03), had higher Charlson Co-morbidity Index (median 7 vs 5, P = 0.0004) and had more advanced chronic kidney disease at baseline (Stages IV and V) (OR 4.38, 95% confidence interval 1.45-13.2, P = 0.01). Conclusion: Empiric gentamicin use in patients with advancing age is associated with low rates of predominantly transient renal impairment.
| Original language | English |
|---|---|
| Pages (from-to) | 227-231 |
| Number of pages | 5 |
| Journal | Australasian Journal on Ageing |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2018 |
Keywords
- Acute kidney injury
- Aminoglycosides
- Gentamicin
- Nephrology
Cite this
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Renal safety of short-term empiric gentamicin therapy in aged patients. / Sia, Christopher Sb; Ananda-Rajah, Michelle R.; Adler, Nikki R.; Yi-Wei, Baey; Liew, Danny; Tong, Erica Y.; Aung, Ar Kar.
In: Australasian Journal on Ageing, Vol. 37, No. 3, 09.2018, p. 227-231.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Renal safety of short-term empiric gentamicin therapy in aged patients
AU - Sia, Christopher Sb
AU - Ananda-Rajah, Michelle R.
AU - Adler, Nikki R.
AU - Yi-Wei, Baey
AU - Liew, Danny
AU - Tong, Erica Y.
AU - Aung, Ar Kar
PY - 2018/9
Y1 - 2018/9
N2 - Objective: To determine the incidence of acute kidney injury (AKI) in aged patients receiving empiric gentamicin therapy. Methods: Patients aged ≥65 years receiving gentamicin upon admission between 2013 and 2015 at two Australian hospitals were retrospectively studied. AKI was defined as a rise in creatinine by ≥50% and/or ≥26.5 μmol/L. Results: Most patients (95%) received a single dose of gentamicin. The incidence of AKI was 15% (36/242 patients). A composite outcome of persistent kidney injury, requirement for renal replacement therapy or inpatient death in a patient with AKI occurred in 10 (4%) patients. Patients who developed AKI were older (median 80.5 vs 78 years, P = 0.03), had higher Charlson Co-morbidity Index (median 7 vs 5, P = 0.0004) and had more advanced chronic kidney disease at baseline (Stages IV and V) (OR 4.38, 95% confidence interval 1.45-13.2, P = 0.01). Conclusion: Empiric gentamicin use in patients with advancing age is associated with low rates of predominantly transient renal impairment.
AB - Objective: To determine the incidence of acute kidney injury (AKI) in aged patients receiving empiric gentamicin therapy. Methods: Patients aged ≥65 years receiving gentamicin upon admission between 2013 and 2015 at two Australian hospitals were retrospectively studied. AKI was defined as a rise in creatinine by ≥50% and/or ≥26.5 μmol/L. Results: Most patients (95%) received a single dose of gentamicin. The incidence of AKI was 15% (36/242 patients). A composite outcome of persistent kidney injury, requirement for renal replacement therapy or inpatient death in a patient with AKI occurred in 10 (4%) patients. Patients who developed AKI were older (median 80.5 vs 78 years, P = 0.03), had higher Charlson Co-morbidity Index (median 7 vs 5, P = 0.0004) and had more advanced chronic kidney disease at baseline (Stages IV and V) (OR 4.38, 95% confidence interval 1.45-13.2, P = 0.01). Conclusion: Empiric gentamicin use in patients with advancing age is associated with low rates of predominantly transient renal impairment.
KW - Acute kidney injury
KW - Aminoglycosides
KW - Gentamicin
KW - Nephrology
UR - http://www.scopus.com/inward/record.url?scp=85046009789&partnerID=8YFLogxK
U2 - 10.1111/ajag.12541
DO - 10.1111/ajag.12541
M3 - Article
VL - 37
SP - 227
EP - 231
JO - Australasian Journal on Ageing
JF - Australasian Journal on Ageing
SN - 1440-6381
IS - 3
ER -