Renal Medulla and Bradykinin during the development of hypertension in SHR

Joseph B. O'Sullivan, John F. Bertram, Stephen B. Harrap

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

1. The long‐term reduction in blood pressure following ACE inhibitor treatment in young spontaneously hypertensive rats (SHR) appears to depend on both the kidney and brady‐kinin. 2. The aim of this experiment was to examine the effects of ACE inhibition and bradykinin on renal morphology and blood pressure in SHR. 3. Between 6 and 10 weeks of age male SHR received one of four treatments: water (n = 26), ramipril (1 mg/kg per day; n = 24), ramipril (1 mg/kg per day) plus Hoe 140 (0.5 mg/kg per day; n = 25) or Hoe 140 (0.5 mg/kg per day; n= 25). 4. Renal medullary and cortical volumes were determined stereologically at 10 and 20 weeks of age. 5. After 4 weeks of treatment, ramipril reduced the size of the renal medulla while Hoe 140 increased medullary volumes compared to control. Ten weeks after treatment was stopped the renal medulla of the ramipril group had returned to normal, however, there was a persistent increase in medullary volume of both Hoe 140 treated groups. 6. Our results imply that bradykinin may influence the size of the renal medulla which may have important effects on the development of hypertension in SHR.

Original languageEnglish
Pages (from-to)463-465
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Volume22
Issue number6-7
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Keywords

  • bradykinin B2 receptor
  • Cavalieri method
  • Hoe 140
  • ramipril
  • renal medulla
  • volume.

Cite this

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abstract = "1. The long‐term reduction in blood pressure following ACE inhibitor treatment in young spontaneously hypertensive rats (SHR) appears to depend on both the kidney and brady‐kinin. 2. The aim of this experiment was to examine the effects of ACE inhibition and bradykinin on renal morphology and blood pressure in SHR. 3. Between 6 and 10 weeks of age male SHR received one of four treatments: water (n = 26), ramipril (1 mg/kg per day; n = 24), ramipril (1 mg/kg per day) plus Hoe 140 (0.5 mg/kg per day; n = 25) or Hoe 140 (0.5 mg/kg per day; n= 25). 4. Renal medullary and cortical volumes were determined stereologically at 10 and 20 weeks of age. 5. After 4 weeks of treatment, ramipril reduced the size of the renal medulla while Hoe 140 increased medullary volumes compared to control. Ten weeks after treatment was stopped the renal medulla of the ramipril group had returned to normal, however, there was a persistent increase in medullary volume of both Hoe 140 treated groups. 6. Our results imply that bradykinin may influence the size of the renal medulla which may have important effects on the development of hypertension in SHR.",
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Renal Medulla and Bradykinin during the development of hypertension in SHR. / O'Sullivan, Joseph B.; Bertram, John F.; Harrap, Stephen B.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 22, No. 6-7, 01.01.1995, p. 463-465.

Research output: Contribution to journalArticleResearchpeer-review

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