Renal effects of cyclo-oxygenase-2 inhibition

Merlin C. Thomas, Ch David Harris

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)


The renal cyclo-oxygenase (COX)-2 isoenzyme has an important role in the maintenance of renal homeostasis, particularly in the setting of reduced renal perfusion. Selective inhibition of COX-2 in the kidney has significant effects on renal physiology, most marked when COX-2 expression is induced. The clinical risk of renal impairment, salt and water retention, and electrolyte disturbance should be considered carefully when prescribing a COX-2 inhibitor in this setting.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
Issue number6
Publication statusPublished - 2 Dec 2002
Externally publishedYes


  • Acute renal failure
  • Coxib
  • Cyclo-oxygenase-2
  • Hyperkalaemia
  • Oedema
  • Perfusion

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