Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 280 - 288 |
| Number of pages | 9 |
| Journal | Circulation |
| Volume | 131 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 |
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Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep. / Lankadeva, Yugeesh Ryan; Singh, Reetu R; Moritz, Karen M; Parkington, Helena C; Denton, Katherine M; Tare, Marianne.
In: Circulation, Vol. 131, No. 3, 2015, p. 280 - 288.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep
AU - Lankadeva, Yugeesh Ryan
AU - Singh, Reetu R
AU - Moritz, Karen M
AU - Parkington, Helena C
AU - Denton, Katherine M
AU - Tare, Marianne
PY - 2015
Y1 - 2015
N2 - BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P
AB - BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P
UR - http://circ.ahajournals.org/content/131/3/280.full.pdf+html
U2 - 10.1161/CIRCULATIONAHA.114.013930
DO - 10.1161/CIRCULATIONAHA.114.013930
M3 - Article
VL - 131
SP - 280
EP - 288
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 3
ER -