Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep

Yugeesh Ryan Lankadeva, Reetu R Singh, Karen M Moritz, Helena C Parkington, Katherine M Denton, Marianne Tare

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P
Original languageEnglish
Pages (from-to)280 - 288
Number of pages9
JournalCirculation
Volume131
Issue number3
DOIs
Publication statusPublished - 2015

Cite this

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title = "Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep",
abstract = "BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P",
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Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep. / Lankadeva, Yugeesh Ryan; Singh, Reetu R; Moritz, Karen M; Parkington, Helena C; Denton, Katherine M; Tare, Marianne.

In: Circulation, Vol. 131, No. 3, 2015, p. 280 - 288.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep

AU - Lankadeva, Yugeesh Ryan

AU - Singh, Reetu R

AU - Moritz, Karen M

AU - Parkington, Helena C

AU - Denton, Katherine M

AU - Tare, Marianne

PY - 2015

Y1 - 2015

N2 - BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P

AB - BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P

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U2 - 10.1161/CIRCULATIONAHA.114.013930

DO - 10.1161/CIRCULATIONAHA.114.013930

M3 - Article

VL - 131

SP - 280

EP - 288

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 3

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