Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep

Yugeesh Ryan Lankadeva; Reetu R Singh; Karen M Moritz; Helena C Parkington; Katherine M Denton; Marianne Tare

doi:10.1161/CIRCULATIONAHA.114.013930

Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep

Yugeesh Ryan Lankadeva, Reetu R Singh, Karen M Moritz, Helena C Parkington, Katherine M Denton, Marianne Tare

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P

Original language	English
Pages (from-to)	280 - 288
Number of pages	9
Journal	Circulation
Volume	131
Issue number	3
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.114.013930
Publication status	Published - 2015

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10.1161/CIRCULATIONAHA.114.013930

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title = "Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep",

abstract = "BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P",

author = "Lankadeva, {Yugeesh Ryan} and Singh, {Reetu R} and Moritz, {Karen M} and Parkington, {Helena C} and Denton, {Katherine M} and Marianne Tare",

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Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep. / Lankadeva, Yugeesh Ryan; Singh, Reetu R; Moritz, Karen M; Parkington, Helena C ; Denton, Katherine M ; Tare, Marianne.

In: Circulation, Vol. 131, No. 3, 2015, p. 280 - 288.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep

AU - Lankadeva, Yugeesh Ryan

AU - Singh, Reetu R

AU - Moritz, Karen M

AU - Parkington, Helena C

AU - Denton, Katherine M

AU - Tare, Marianne

PY - 2015

Y1 - 2015

N2 - BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P

AB - BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P

UR - http://circ.ahajournals.org/content/131/3/280.full.pdf+html

U2 - 10.1161/CIRCULATIONAHA.114.013930

DO - 10.1161/CIRCULATIONAHA.114.013930

M3 - Article

VL - 131

SP - 280

EP - 288

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 3

ER -