Renal dysfunction is associated with a reduced contribution of nitric oxide and enhanced vasoconstriction after a congenital renal mass reduction in sheep

Yugeesh Ryan Lankadeva, Reetu R Singh, Karen M Moritz, Helena C Parkington, Katherine M Denton, Marianne Tare

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12 Citations (Scopus)

Abstract

BACKGROUND: -Children born with reduced congenital renal mass have increased risk of hypertension and chronic kidney disease in adulthood, though mechanisms are poorly understood. Similar sequelae occur following fetal uninephrectomy (uni-x) in sheep leading to a 30 nephron deficit. We hypothesized that renal dysfunction is underpinned by a reduced contribution of nitric oxide (NO) and vascular dysfunction in uni-x sheep. METHODS AND RESULTS: -In 5-year old female uni-x and sham sheep, mean arterial pressure (MAP), glomerular filtration rate (GFR) and renal blood flow (RBF) were measured before and during NO inhibition (L-NAME). Reactivity was assessed in resistance arteries including renal lobar and arcuate arteries. Basal MAP was 15mmHg higher, GFR and RBF 30 lower (P
Original languageEnglish
Pages (from-to)280 - 288
Number of pages9
JournalCirculation
Volume131
Issue number3
DOIs
Publication statusPublished - 2015

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