Renal Denervation: A Treatment for Hypertension and Chronic Kidney Disease

Renal sympathetic overactivity contributes to the development and progression of hypertension and chronic kidney disease (CKD).1–3 Conversely, progressive decline in renal function can exacerbate sympathetic overactivity.4,5 Renal denervation (RDN) in experimental models of hypertension and CKD has been shown to reduce blood pressure (BP) and improve renal function, which laid the foundation for the introduction of RDN to clinical practice.6 Although the efficacy of RDN as a treatment for hypertension has been disputed, the majority of data suggest that there is a place for RDN in the clinic and trials are ongoing (Table).