The α adrenoceptors modulate renal blood flow, electrolyte balance, and metabolism. In most species both α1 and α2 subtypes are present. The α1 adrenoceptors control blood flow and increase sodium reabsorption and gluconeogenesis. Radioligand studies indicate that the majority of α1 adrenoceptors are located on proximal tubules. The α2 adrenoceptors inhibit adenylate cyclase, and their density varies among species as do the molecular characteristics. In rat but not guinea pig some α2 adrenoceptors are associated with glomeruli, but in both species most receptors are found on proximal tubules.
|Number of pages||6|
|Publication status||Published - 1 Dec 1984|