TY - JOUR
T1 - Remodelling the malignant phenotype: Impact of EMT
AU - Said, Nur Akmarina Binti Mohd
AU - Williams, Elizabeth
PY - 2009
Y1 - 2009
N2 - Epithelial to mesenchymal transition (EMT) is a highly conserved programme of events essential for normal development. As it underpins cell plasticity, migration and invasion in a number of settings it is an attractive concept to apply to the malignant phenotype. Much is known about the molecular events regulating EMT in a number of model organisms, including Drosophila, sea urchin, zebrafish, xenopus and the chick. It is increasingly apparent that EMT is a highly conserved process, and that discoveries made in these systems provide excellent insights into the understanding of the role of EMT in human malignancies.
AB - Epithelial to mesenchymal transition (EMT) is a highly conserved programme of events essential for normal development. As it underpins cell plasticity, migration and invasion in a number of settings it is an attractive concept to apply to the malignant phenotype. Much is known about the molecular events regulating EMT in a number of model organisms, including Drosophila, sea urchin, zebrafish, xenopus and the chick. It is increasingly apparent that EMT is a highly conserved process, and that discoveries made in these systems provide excellent insights into the understanding of the role of EMT in human malignancies.
UR - http://dx.doi.org/10.1016/j.ddmod.2008.12.002
U2 - 10.1016/j.ddmod.2008.12.002
DO - 10.1016/j.ddmod.2008.12.002
M3 - Article
SN - 1359-6446
VL - 6
SP - 21
EP - 25
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 1
ER -