TY - JOUR
T1 - Remarkable in vitro bactericidal activity of bismuth(III) sulfonates against Helicobacter pylori
AU - Andrews, Philip Craig
AU - Busse, Madleen
AU - Deacon, Glen Berenger
AU - Ferrero, Richard Louis
AU - Junk, Peter Courtney
AU - Maclellan, Jonathan G
AU - Vom, Amelia
PY - 2012
Y1 - 2012
N2 - Four new tris-substituted bismuth(III) sulfonates of general formula [Bi(O3SR)(3)] (R = phenyl 1, p-tolyl 2, 2,4,6-mesityl 3 and S-(+)-10-camphoryl 4) have been synthesised and characterised. Their synthesis by solvent-free (SF) and solvent-mediated (SM) methods has been explored and their activity against Helicobacter pylori has been investigated. The compounds 1-4 display a remarkable in vitro activity against three laboratory strains of H. pylori (B128, 26 695 and 251) with minimum inhibitory concentration (MIC) values as low as 0.049 mu g mL(-1) for the strains B128 and 26 695, and 0.781 mu g mL(-1) for the clinical isolate 251. This places most MIC values in the nano-molar region and demonstrates the strong influence of the sulfonate group on the bactericidal properties. The novel solid state structure [Bi-8(O(3)SMes)(20)(SO4)(2)(H2O)(6)]center dot(C7H8)(7) 5 center dot(C(7)H8)(7), derived from the SM reaction under reflux conditions, is presented and the incorporation of the two inorganic sulfate anions in the centre of the wheel-like bismuth sulfonate cluster explained.
AB - Four new tris-substituted bismuth(III) sulfonates of general formula [Bi(O3SR)(3)] (R = phenyl 1, p-tolyl 2, 2,4,6-mesityl 3 and S-(+)-10-camphoryl 4) have been synthesised and characterised. Their synthesis by solvent-free (SF) and solvent-mediated (SM) methods has been explored and their activity against Helicobacter pylori has been investigated. The compounds 1-4 display a remarkable in vitro activity against three laboratory strains of H. pylori (B128, 26 695 and 251) with minimum inhibitory concentration (MIC) values as low as 0.049 mu g mL(-1) for the strains B128 and 26 695, and 0.781 mu g mL(-1) for the clinical isolate 251. This places most MIC values in the nano-molar region and demonstrates the strong influence of the sulfonate group on the bactericidal properties. The novel solid state structure [Bi-8(O(3)SMes)(20)(SO4)(2)(H2O)(6)]center dot(C7H8)(7) 5 center dot(C(7)H8)(7), derived from the SM reaction under reflux conditions, is presented and the incorporation of the two inorganic sulfate anions in the centre of the wheel-like bismuth sulfonate cluster explained.
UR - http://pubs.rsc.org/en/content/articlepdf/2012/dt/c2dt31360j
U2 - 10.1039/c2dt31360j
DO - 10.1039/c2dt31360j
M3 - Article
SN - 1477-9226
VL - 41
SP - 11798
EP - 11806
JO - Dalton Transactions
JF - Dalton Transactions
IS - 38
ER -