Relaxin regulates collagen overproduction associated with experimental progressive renal fibrosis

Chrishan Samuel, Ishanee Mookerjee, Rosemary Masterson, Geoffrey Tregear, Tim Hewitson

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Progressive fibrosis due to excess extracellular matrix (primarily collagen) is the final common pathway in all forms of chronic renal disease, regardless of etiology, and leads to tissue dysfunction, when normal tissue is replaced by scar tissue. Emerging work from ourselves and others suggests that the naturally occurring hormone relaxin has the potential to limit renal collagen production and reorganization, while increasing its degradation. The outlined studies demonstrate relaxin s potential as an antifibrotic agent against experimental progressive renal disease.
Original languageEnglish
Pages (from-to)182 - 184
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume1041
DOIs
Publication statusPublished - 2005
Externally publishedYes

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