Relaxin in human pregnancy serum measured with an homologous radioimmunoassay

R. J. Bell, L. W. Eddie, A. R. Lester, E. C. Wood, P. D. Johnston, H. D. Niall

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Abstract

This study reports serum levels of relaxin in normal and special-interest pregnancies using an homologous radioimmunoassay for human relaxin. The mean levels in uncom- plicated antenatal patients were lower than those reported in studies using heterologous assays, but the trend in serum levels was similar. Serum levels peaked at ten weeks' gestation and decreased progressively to term. Relaxin was detectable in all pregnant subjects assessed at the time of the first missed menses. The mean relaxin levels in patients having in vitro fertilization and embryo transfer who sub- sequently delivered a single infant were significantly higher than those in normal antenatal patients at an equivalent gestational age. Patients with twin pregnancies after in vitro fertilization and embryo transfer generally had higher levels than patients with single pregnancies. Some pregnant pa- tients who aborted after in vitro fertilization and embryo transfer had declining levels of relaxin before 40 days postlaparoscopy.

Original languageEnglish
Pages (from-to)585-589
Number of pages5
JournalObstetrics and Gynecology
Volume69
Issue number4
Publication statusPublished - 1 Jan 1987

Cite this

Bell, R. J., Eddie, L. W., Lester, A. R., Wood, E. C., Johnston, P. D., & Niall, H. D. (1987). Relaxin in human pregnancy serum measured with an homologous radioimmunoassay. Obstetrics and Gynecology, 69(4), 585-589.