Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes

Xiao-Lei Moore, Su-Ling Tan, Chen-Yi Lo, Lu Fang, Yi-Dan Su, Xiao-Ming Gao, Elizabeth A Woodcock, Roger James Summers, Geoffrey W Tregear, Ross Bathgate, Xia-Jun Du

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Abstract

The pregnancy hormone relaxin has recently been shown to be cardio-protective. Despite its well-established anti-fibrotic actions in the heart, the effects of relaxin on cardiomyocytes (CM) remain to be determined. We investigated effects of isoform 2 of the human relaxin (H2-relaxin) on CM hypertrophy and apoptosis. In cultured neonatal rat CM, phenylephrine (50 microM) and cardiac fibroblast-conditioned medium (FCM) were used respectively to induce CM hypertrophy. The degree of hypertrophy was indicated by increased cell size, protein synthesis and gene expression of atrial natriuretic peptide (ANP). Whilst H2-relaxin (16.7 nM) alone failed to suppress hypertrophy induced by phenylephrine, it repressed the FCM-induced increase in protein synthesis by 24 (P
Original languageEnglish
Pages (from-to)1582 - 1589
Number of pages8
JournalEndocrinology
Volume148
Issue number4
Publication statusPublished - 2007

Cite this

Moore, X-L., Tan, S-L., Lo, C-Y., Fang, L., Su, Y-D., Gao, X-M., Woodcock, E. A., Summers, R. J., Tregear, G. W., Bathgate, R., & Du, X-J. (2007). Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. Endocrinology, 148(4), 1582 - 1589.