TY - JOUR
T1 - Relaxin and extracellular matrix remodeling
T2 - Mechanisms and signaling pathways
AU - Ng, Hooi Hooi
AU - Shen, Matthew
AU - Samuel, Chrishan S.
AU - Schlossmann, Jens
AU - Bennett, Robert G.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Fibrosis is associated with accumulation of excess fibrillar collagen, leading to tissue dysfunction. Numerous processes, including inflammation, myofibroblast activation, and endothelial-to-mesenchymal transition, play a role in the establishment and progression of fibrosis. Relaxin is a peptide hormone with well-known antifibrotic properties that result from its action on numerous cellular targets to reduce fibrosis. Relaxin activates multiple signal transduction pathways as a mechanism to suppress inflammation and myofibroblast activation in fibrosis. In this review, the general mechanisms underlying fibrotic diseases are described, along with the current state of knowledge regarding cellular targets of relaxin. Finally, an overview is presented summarizing the signaling pathways activated by relaxin and other relaxin family peptide receptor agonists to suppress fibrosis.
AB - Fibrosis is associated with accumulation of excess fibrillar collagen, leading to tissue dysfunction. Numerous processes, including inflammation, myofibroblast activation, and endothelial-to-mesenchymal transition, play a role in the establishment and progression of fibrosis. Relaxin is a peptide hormone with well-known antifibrotic properties that result from its action on numerous cellular targets to reduce fibrosis. Relaxin activates multiple signal transduction pathways as a mechanism to suppress inflammation and myofibroblast activation in fibrosis. In this review, the general mechanisms underlying fibrotic diseases are described, along with the current state of knowledge regarding cellular targets of relaxin. Finally, an overview is presented summarizing the signaling pathways activated by relaxin and other relaxin family peptide receptor agonists to suppress fibrosis.
KW - cGMP
KW - Fibrosis
KW - Nitric oxide
KW - Relaxin
KW - Relaxin family peptidereceptor
KW - Relaxin family peptides
UR - http://www.scopus.com/inward/record.url?scp=85060259502&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2019.01.015
DO - 10.1016/j.mce.2019.01.015
M3 - Review Article
C2 - 30660699
AN - SCOPUS:85060259502
VL - 487
SP - 59
EP - 65
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
ER -