Relaxin: An emerging therapy for fibroproliferative disorders

Chrishan Surendran Samuel

doi:10.1007/978-3-642-22697-7_48

Relaxin: An emerging therapy for fibroproliferative disorders

Chrishan Surendran Samuel

Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

Abstract

Relaxin is a member of the insulin family of peptides. It is produced in the corpus luteum and/or placenta during pregnancy in mammals and is secreted into the blood where it has numerous essential endocrine functions. In addition to long-recognized roles in remodeling of reproductive tissues, it has an important role as a cardiovascular hormone during pregnancy with potent vasodilatory and renal actions. Additionally, relaxin has potent effects on collagen turnover in connective tissue. The positive effects of relaxin in induced fibrosis models show a significant role in ameliorating kidney, heart and lung fibrosis. Much work has thus been undertaken on the structure and function relationship of this peptide with the goal of understanding the molecular basis for relaxin s action and developing mimetics with potential therapeutic applications in fibrosis.

Original language	English
Title of host publication	Dupuytren's Disease and Related Hyperproliferative Disorders
Editors	C Eaton, M H Seegenschmiedt, A Bayat, G Gabbiani, P M N Werker, W Wach
Place of Publication	Germany
Publisher	Springer
Pages	393 - 400
Number of pages	8
Edition	1st
ISBN (Print)	978-3-642-22696-0
DOIs	https://doi.org/10.1007/978-3-642-22697-7_48
Publication status	Published - 2012

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10.1007/978-3-642-22697-7_48

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abstract = "Relaxin is a member of the insulin family of peptides. It is produced in the corpus luteum and/or placenta during pregnancy in mammals and is secreted into the blood where it has numerous essential endocrine functions. In addition to long-recognized roles in remodeling of reproductive tissues, it has an important role as a cardiovascular hormone during pregnancy with potent vasodilatory and renal actions. Additionally, relaxin has potent effects on collagen turnover in connective tissue. The positive effects of relaxin in induced fibrosis models show a significant role in ameliorating kidney, heart and lung fibrosis. Much work has thus been undertaken on the structure and function relationship of this peptide with the goal of understanding the molecular basis for relaxin s action and developing mimetics with potential therapeutic applications in fibrosis.",

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Relaxin: An emerging therapy for fibroproliferative disorders. / Samuel, Chrishan Surendran.

Dupuytren's Disease and Related Hyperproliferative Disorders. ed. / C Eaton; M H Seegenschmiedt; A Bayat; G Gabbiani; P M N Werker; W Wach. 1st. ed. Germany : Springer, 2012. p. 393 - 400.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

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N2 - Relaxin is a member of the insulin family of peptides. It is produced in the corpus luteum and/or placenta during pregnancy in mammals and is secreted into the blood where it has numerous essential endocrine functions. In addition to long-recognized roles in remodeling of reproductive tissues, it has an important role as a cardiovascular hormone during pregnancy with potent vasodilatory and renal actions. Additionally, relaxin has potent effects on collagen turnover in connective tissue. The positive effects of relaxin in induced fibrosis models show a significant role in ameliorating kidney, heart and lung fibrosis. Much work has thus been undertaken on the structure and function relationship of this peptide with the goal of understanding the molecular basis for relaxin s action and developing mimetics with potential therapeutic applications in fibrosis.

AB - Relaxin is a member of the insulin family of peptides. It is produced in the corpus luteum and/or placenta during pregnancy in mammals and is secreted into the blood where it has numerous essential endocrine functions. In addition to long-recognized roles in remodeling of reproductive tissues, it has an important role as a cardiovascular hormone during pregnancy with potent vasodilatory and renal actions. Additionally, relaxin has potent effects on collagen turnover in connective tissue. The positive effects of relaxin in induced fibrosis models show a significant role in ameliorating kidney, heart and lung fibrosis. Much work has thus been undertaken on the structure and function relationship of this peptide with the goal of understanding the molecular basis for relaxin s action and developing mimetics with potential therapeutic applications in fibrosis.

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EP - 400

BT - Dupuytren's Disease and Related Hyperproliferative Disorders

A2 - Eaton, C

A2 - Seegenschmiedt, M H

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A2 - Gabbiani, G

A2 - Werker, P M N

A2 - Wach, W

PB - Springer

CY - Germany

ER -

Relaxin: An emerging therapy for fibroproliferative disorders

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