Relationships between adult asthma and oxidative stress markers and pH in exhaled breath condensate: A systematic review

F. M. Aldakheel, P. S. Thomas, J. E. Bourke, M. C. Matheson, S. C. Dharmage, A. J. Lowe

Research output: Contribution to journalReview ArticleResearchpeer-review

29 Citations (Scopus)


Oxidative stress has a recognised role in the pathophysiology of asthma. Recently, interest has increased in the assessment of pH and airway oxidative stress markers. Collection of exhaled breath condensate (EBC) and quantification of biomarkers in breath samples can potentially indicate lung disease activity and help in the study of airway inflammation, and asthma severity. Levels of oxidative stress markers in the EBC have been systematically evaluated in children with asthma; however, there is no such systematic review conducted for adult asthma. A systematic review of oxidative stress markers measured in EBC of adult asthma was conducted and studies were identified by searching MEDLINE and SCOPUS databases. Sixteen papers met the inclusion criteria. Concentrations of exhaled hydrogen ions, nitric oxide products, hydrogen peroxide and 8-isoprostanes were generally elevated and related to lower lung function tests in adults with asthma compared to healthy subjects. Assessment of EBC markers may be a non-invasive approach to evaluate airway inflammation, exacerbations, and disease severity of asthma, and to monitor the effectiveness of anti-inflammatory treatment regimens. Longitudinal studies, using standardised analytical techniques for EBC collection, are required to establish reference values for interpretation of EBC markers in the context of asthma.
Original languageEnglish
Pages (from-to)741-757
Number of pages17
Issue number6
Publication statusPublished - Jun 2016


  • asthma
  • exhaled breath condensate
  • oxidative stress
  • pH
  • reactive oxygen species

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