Relationship of psychotic symptoms to haloperidol‐stimulated prolactin release

J. Kulkarni, N. A. Keks, G. Stuart, B. Mackie, I. H. Minas, B. S. Singh, D. L. Copolov

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Prolactin (PRL) response to a single dose of intravenous haloperidol (0.5 mg) was measured as a marker of tuberoinfundibular dopamine (TIDA) activity in 24 neuroleptic‐free, male, psychotic patients. The PRL responses were then correlated with psychotic symptoms measured with Andreasen's Scales for the Assessment of Positive and Negative Symptoms (SAPS, SANS). Correlation analyses revealed a significant inverse relationship between PRL response and the severity of delusional symptoms. There was no significant correlation between the symptoms of hallucinations, formal thought disorder, or global negative symptoms and PRL response to haloperidol, nor were there any significant correlations between basal PRL and symptom severity. These results suggest that among the positive and negative symptoms associated with psychoses, only delusions may be associated with TIDA overactivity.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalActa Psychiatrica Scandinavica
Volume82
Issue number4
DOIs
Publication statusPublished - 1 Jan 1990

Keywords

  • delusion
  • haloperidol
  • prolactin
  • psychosis
  • schizophrenia

Cite this

Kulkarni, J. ; Keks, N. A. ; Stuart, G. ; Mackie, B. ; Minas, I. H. ; Singh, B. S. ; Copolov, D. L. / Relationship of psychotic symptoms to haloperidol‐stimulated prolactin release. In: Acta Psychiatrica Scandinavica. 1990 ; Vol. 82, No. 4. pp. 271-274.
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Relationship of psychotic symptoms to haloperidol‐stimulated prolactin release. / Kulkarni, J.; Keks, N. A.; Stuart, G.; Mackie, B.; Minas, I. H.; Singh, B. S.; Copolov, D. L.

In: Acta Psychiatrica Scandinavica, Vol. 82, No. 4, 01.01.1990, p. 271-274.

Research output: Contribution to journalArticleResearchpeer-review

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