Relationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients

Siow Chin Heng, Gregory I Snell, Bronwyn Levvey, Dominic T Keating, Glen P Westall, Trevor John Williams, H Whitford, Roger Leigh Nation, Monica Anne Slavin, Orla Morrissey, David Chee Ming Kong

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Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (?standard deviation [SD]) ELF/plasma ratio was 12.5?6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r2=0.87), suggesting the feasibility of using trough plasma voriconazole concentration as a surrogate to estimate the corresponding concentration in ELF of lung transplant recipients. Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)4581-4583
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number9
Publication statusPublished - 2013

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