Relationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients

Research output: Contribution to journalArticleOtherpeer-review

12 Citations (Scopus)

Abstract

Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (?standard deviation [SD]) ELF/plasma ratio was 12.5?6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r2=0.87), suggesting the feasibility of using trough plasma voriconazole concentration as a surrogate to estimate the corresponding concentration in ELF of lung transplant recipients. Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)4581 - 4583
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number9
DOIs
Publication statusPublished - 2013

Cite this

@article{db105e12046048ec84c00440e78b3e30,
title = "Relationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients",
abstract = "Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (?standard deviation [SD]) ELF/plasma ratio was 12.5?6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r2=0.87), suggesting the feasibility of using trough plasma voriconazole concentration as a surrogate to estimate the corresponding concentration in ELF of lung transplant recipients. Copyright ? 2013, American Society for Microbiology. All Rights Reserved.",
author = "Heng, {Siow Chin} and Snell, {Gregory I} and Bronwyn Levvey and Keating, {Dominic T} and Westall, {Glen P} and Williams, {Trevor John} and H Whitford and Nation, {Roger Leigh} and Slavin, {Monica Anne} and Orla Morrissey and Kong, {David Chee Ming}",
year = "2013",
doi = "10.1128/AAC.00942-13",
language = "English",
volume = "57",
pages = "4581 -- 4583",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "1098-6596",
publisher = "American Society for Microbiology",
number = "9",

}

TY - JOUR

T1 - Relationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients

AU - Heng, Siow Chin

AU - Snell, Gregory I

AU - Levvey, Bronwyn

AU - Keating, Dominic T

AU - Westall, Glen P

AU - Williams, Trevor John

AU - Whitford, H

AU - Nation, Roger Leigh

AU - Slavin, Monica Anne

AU - Morrissey, Orla

AU - Kong, David Chee Ming

PY - 2013

Y1 - 2013

N2 - Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (?standard deviation [SD]) ELF/plasma ratio was 12.5?6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r2=0.87), suggesting the feasibility of using trough plasma voriconazole concentration as a surrogate to estimate the corresponding concentration in ELF of lung transplant recipients. Copyright ? 2013, American Society for Microbiology. All Rights Reserved.

AB - Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (?standard deviation [SD]) ELF/plasma ratio was 12.5?6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r2=0.87), suggesting the feasibility of using trough plasma voriconazole concentration as a surrogate to estimate the corresponding concentration in ELF of lung transplant recipients. Copyright ? 2013, American Society for Microbiology. All Rights Reserved.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754345/pdf/zac4581.pdf

U2 - 10.1128/AAC.00942-13

DO - 10.1128/AAC.00942-13

M3 - Article

VL - 57

SP - 4581

EP - 4583

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 1098-6596

IS - 9

ER -