Relationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients
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Trough (predose) voriconazole concentrations in plasma and pulmonary epithelial lining fluid (ELF) of lung transplant recipients receiving oral voriconazole preemptive treatment were determined. The mean (?standard deviation [SD]) ELF/plasma ratio was 12.5?6.3. A strong positive linear relationship was noted between trough plasma and ELF voriconazole concentrations (r2=0.87), suggesting the feasibility of using trough plasma voriconazole concentration as a surrogate to estimate the corresponding concentration in ELF of lung transplant recipients. Copyright ? 2013, American Society for Microbiology. All Rights Reserved.