Relationship between pituitary nuclear oestrogen receptors and the release of LH, FSH and prolactin in the ewe

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Abstract

Ovariectomized ewes were given a single injection (i.v.) of 100 μg oestradiol-17β. Nuclear oestrogen receptor values in the pituitary, as a function of total receptor concentrations, were 3.0 ± 1.0% in controls, 56.0 ± 5.4% at 1 h (P<0.001) and 6.5 ± 2.1% at 6 h (P>0.05) after oestradiol injection. There was a fall in plasma LH values from 5.7 ± 1.0 (preinjection) to 2.1 ± 0.3 ng/ml (P<0.01) 4-6 h after oestradiol. At 13-21 h after injection plasma levels increased to 37 ± 8 ng/ml (P<0.001). Plasma FSH levels declined from 840 ± 18 to 506 ± 48 ng/ml after 20-22 h (P<0.001). Plasma prolactin concentrations fell from 90 ± 16 ng/ml before injection to 29 ± 9 ng/ml at 1 h (P>0.05), and then rose to a maximum of 1537 ± 24 ng/ml (P<0.001) 11-14 h later. These results show that transient nuclear compartmentalization of oestrogen receptors after a bolus injection of oestradiol was associated with the feedback effects of oestradiol on LH, FSH and prolactin release.

Original languageEnglish
Pages (from-to)355-362
Number of pages8
JournalJournal of Reproduction and Fertility
Volume64
Issue number2
DOIs
Publication statusPublished - 1 Jan 1982
Externally publishedYes

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