Relationship between P50 suppression and the cortical silent period

Bertram Möller, Gregory A. Light, Paul B. Fitzgerald, Joel S. Snyder, Robert Chen, Zafiris J. Daskalakis

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7 Citations (Scopus)

Abstract

Deficient inhibitory neurotransmission has been demonstrated in schizophrenia through electroencephalography (e.g. P50 suppression) and transcranial magnetic stimulation (e.g. short-interval cortical inhibition and the cortical silent period). It is not known whether these inhibitory paradigms are related despite evidence suggesting that both are coordinated through γ-aminobutyric acid inhibitory neurotransmission. We explored the relationship between P50 suppression, short-interval cortical inhibition and the cortical silent period in 21 healthy participants using previously published methods. P50 suppression was significantly correlated with cortical silent period (r=-0.49, P=0.02) but not with short-interval cortical inhibition. As both P50 suppression and the cortical silent period have been linked to γ-aminobutyric acidB receptor-mediated inhibitory neurotransmission, these data highlight the importance of this receptor subtype in the pathophysiology of schizophrenia.

Original languageEnglish
Pages (from-to)1503-1506
Number of pages4
JournalNeuroReport
Volume18
Issue number14
DOIs
Publication statusPublished - 1 Sept 2007

Keywords

  • Cortical inhibition
  • Cortical silent period
  • GABA
  • Neurophysiology
  • P50 suppression
  • Schizophrenia

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