Abstract
Deficient inhibitory neurotransmission has been demonstrated in schizophrenia through electroencephalography (e.g. P50 suppression) and transcranial magnetic stimulation (e.g. short-interval cortical inhibition and the cortical silent period). It is not known whether these inhibitory paradigms are related despite evidence suggesting that both are coordinated through γ-aminobutyric acid inhibitory neurotransmission. We explored the relationship between P50 suppression, short-interval cortical inhibition and the cortical silent period in 21 healthy participants using previously published methods. P50 suppression was significantly correlated with cortical silent period (r=-0.49, P=0.02) but not with short-interval cortical inhibition. As both P50 suppression and the cortical silent period have been linked to γ-aminobutyric acidB receptor-mediated inhibitory neurotransmission, these data highlight the importance of this receptor subtype in the pathophysiology of schizophrenia.
Original language | English |
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Pages (from-to) | 1503-1506 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 18 |
Issue number | 14 |
DOIs | |
Publication status | Published - 1 Sept 2007 |
Keywords
- Cortical inhibition
- Cortical silent period
- GABA
- Neurophysiology
- P50 suppression
- Schizophrenia