Relationship between indices of adiposity obtained by peripheral quantitative computed tomography and dual-energy X-ray absorptiometry in pre-pubertal children

G. Ducher, R. M. Daly, B. Hill, P. Eser, G. A. Naughton, K. J. Gravenmaker, M. J. Seibel, A. Javaid, R. D. Telford, S. L. Bass

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Abstract

Background/Aim: The study investigated the relationship between indices of adiposity measured by peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA) in pre-pubertal children. Subjects and methods: DXA-derived per cent body fat (%BF) was measured in 284 boys and 288 girls, aged 710 years. Cross-sections of the forearm (n=427) and lower leg (n=560) were obtained by pQCT to measure total cross-sectional area of the limb (Total CSA), Muscle CSA, Fat CSA, %Fat CSA (Fat CSA/Total CSA×100) and muscle density. Results: Peripheral QCT-derived %Fat CSA in the forearm and lower leg correlated strongly with DXA-derived %BF (r=0.830.89, p<0.01) in both boys and girls. However, forearm and lower leg %Fat CSA were higher than whole body %BF by 5% and 10%, respectively. A better prediction of whole-body %BF was achieved by including %Fat CSA, muscle density and height into a hierarchical regression model. Using sex-specific regression equations, 87.7% of the boys and 83.7% of the girls had a predicted %BF within 3% units of the %BF obtained by DXA. Conclusion: In pre-pubertal children, pQCT measures of adiposity are strongly associated with whole-body per cent body fat. This reproducible method could be an alternative technique to estimate body composition in this population.

Original languageEnglish
Pages (from-to)705-716
Number of pages12
JournalAnnals of Human Biology
Volume36
Issue number6
DOIs
Publication statusPublished - 31 Dec 2009
Externally publishedYes

Keywords

  • Body composition
  • Body fat
  • Muscle density
  • Obesity
  • Pre-puberty

Cite this

Ducher, G., Daly, R. M., Hill, B., Eser, P., Naughton, G. A., Gravenmaker, K. J., Seibel, M. J., Javaid, A., Telford, R. D., & Bass, S. L. (2009). Relationship between indices of adiposity obtained by peripheral quantitative computed tomography and dual-energy X-ray absorptiometry in pre-pubertal children. Annals of Human Biology, 36(6), 705-716. https://doi.org/10.3109/03014460903055139