Relationship between heart rate variability and angiotensinogen gene polymorphism in diabetic and control individuals

Faezeh Marzbanrad, Brett Hambly, Ethan Ng, Mikhail Tamayo, Slade Matthews, Chandan Karmakar, Ahsan H. Khandoker, Marimuthu Palaniswami, Herbet F. Jelinek

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

2 Citations (Scopus)


Heart Rate Variability (HRV) is extensively used to investigate general Autonomic Nervous System (ANS) function and is affected by many factors including age, gender, pathology such as diabetes and genetic polymorphisms. One of these genetic polymorphisms is the Angiotensin Converting Enzyme (ACE) polymorphism corresponding to insertion (I) or deletion (D) of a 287-base pair sequence of DNA in intron 16 of the ACE gene (rs4340). Some studies have addressed the relationship between HRV and D/D, I/D and I/I ACE polymorphism while others combined I/D and I/I ACE groups. In this study HRV is determined for diabetic and control individuals with different ACE polymorphism considering either separate or combined I/D and I/I genotypes. Linear time domain parameters, entropy, low frequency and total power of HRV were found to be significantly different between diabetic and control individuals with combined I/I and I/D ACE polymorphism, while only entropy was different for diabetic and control subjects with D/D ACE genotype. Separate analysis of I/I and I/D genotypes was preferred for a thorough investigation of HRV and ACE polymorphism, as the combined analysis masked some differences in HRV parameters such as Poincar´e plot between ACE polymorphisms and diabetes status. Furthermore, a separate analysis demonstrated that most of the significant differences for HRV were between the diabetic group with I/I genotype and I/D and D/D groups.
Original languageEnglish
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
EditorsJeff Duerk, Jim Ji
Place of PublicationPiscataway NJ USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages4
ISBN (Electronic)9781424479290
ISBN (Print)9781424479276
Publication statusPublished - 6 Nov 2014
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2014 - Sheraton Chicago Hotel and Towers, Chicago, United States of America
Duration: 26 Aug 201430 Aug 2014
Conference number: 36th (Proceedings) (Website)


ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2014
Abbreviated titleEMBC 2014
CountryUnited States of America
Internet address

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