Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: a cross-sectional, observational study

Peter Raymond Gibson, Carolynne J Vaizey, Christopher M Black, Rebecca Nicholls, Adele R Weston, Peter A Bampton, Miles Patrick Sparrow, Ian Lawrance, Warwick S Selby, Jane M Andrews, Alissa Walsh, David Hetzel, Finlay A Macrae, Gregory Thomas Charles Moore, Martin D Weltman, Rupert Wing Loong Leong, Tao Fan

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64 Citations (Scopus)


The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps.
Original languageEnglish
Pages (from-to)598 - 606
Number of pages9
JournalJournal of Crohn's and Colitis
Issue number7
Publication statusPublished - 2014

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