Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: a cross-sectional, observational study

Peter Raymond Gibson, Carolynne J Vaizey, Christopher M Black, Rebecca Nicholls, Adele R Weston, Peter A Bampton, Miles Patrick Sparrow, Ian Lawrance, Warwick S Selby, Jane M Andrews, Alissa Walsh, David Hetzel, Finlay A Macrae, Gregory Thomas Charles Moore, Martin D Weltman, Rupert Wing Loong Leong, Tao Fan

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps.
Original languageEnglish
Pages (from-to)598 - 606
Number of pages9
JournalJournal of Crohn's and Colitis
Volume8
Issue number7
DOIs
Publication statusPublished - 2014

Cite this

Gibson, Peter Raymond ; Vaizey, Carolynne J ; Black, Christopher M ; Nicholls, Rebecca ; Weston, Adele R ; Bampton, Peter A ; Sparrow, Miles Patrick ; Lawrance, Ian ; Selby, Warwick S ; Andrews, Jane M ; Walsh, Alissa ; Hetzel, David ; Macrae, Finlay A ; Moore, Gregory Thomas Charles ; Weltman, Martin D ; Leong, Rupert Wing Loong ; Fan, Tao. / Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: a cross-sectional, observational study. In: Journal of Crohn's and Colitis. 2014 ; Vol. 8, No. 7. pp. 598 - 606.
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title = "Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: a cross-sectional, observational study",
abstract = "The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps.",
author = "Gibson, {Peter Raymond} and Vaizey, {Carolynne J} and Black, {Christopher M} and Rebecca Nicholls and Weston, {Adele R} and Bampton, {Peter A} and Sparrow, {Miles Patrick} and Ian Lawrance and Selby, {Warwick S} and Andrews, {Jane M} and Alissa Walsh and David Hetzel and Macrae, {Finlay A} and Moore, {Gregory Thomas Charles} and Weltman, {Martin D} and Leong, {Rupert Wing Loong} and Tao Fan",
year = "2014",
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language = "English",
volume = "8",
pages = "598 -- 606",
journal = "Journal of Crohn's and Colitis",
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Gibson, PR, Vaizey, CJ, Black, CM, Nicholls, R, Weston, AR, Bampton, PA, Sparrow, MP, Lawrance, I, Selby, WS, Andrews, JM, Walsh, A, Hetzel, D, Macrae, FA, Moore, GTC, Weltman, MD, Leong, RWL & Fan, T 2014, 'Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: a cross-sectional, observational study', Journal of Crohn's and Colitis, vol. 8, no. 7, pp. 598 - 606. https://doi.org/10.1016/j.crohns.2013.11.017

Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: a cross-sectional, observational study. / Gibson, Peter Raymond; Vaizey, Carolynne J; Black, Christopher M; Nicholls, Rebecca; Weston, Adele R; Bampton, Peter A; Sparrow, Miles Patrick; Lawrance, Ian; Selby, Warwick S; Andrews, Jane M; Walsh, Alissa; Hetzel, David; Macrae, Finlay A; Moore, Gregory Thomas Charles; Weltman, Martin D; Leong, Rupert Wing Loong; Fan, Tao.

In: Journal of Crohn's and Colitis, Vol. 8, No. 7, 2014, p. 598 - 606.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Relationship between disease severity and quality of life and assessment of health care utilization and cost for ulcerative colitis in Australia: a cross-sectional, observational study

AU - Gibson, Peter Raymond

AU - Vaizey, Carolynne J

AU - Black, Christopher M

AU - Nicholls, Rebecca

AU - Weston, Adele R

AU - Bampton, Peter A

AU - Sparrow, Miles Patrick

AU - Lawrance, Ian

AU - Selby, Warwick S

AU - Andrews, Jane M

AU - Walsh, Alissa

AU - Hetzel, David

AU - Macrae, Finlay A

AU - Moore, Gregory Thomas Charles

AU - Weltman, Martin D

AU - Leong, Rupert Wing Loong

AU - Fan, Tao

PY - 2014

Y1 - 2014

N2 - The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps.

AB - The burden of ulcerative colitis (UC) in relation to disease severity is not well documented. This study quantitatively evaluated the relationship between disease activity and quality of life (QoL), as well as health care utilization, cost, and work-related impairment associated with UC in an Australian population. Methods: A cross-sectional, noninterventional, observational study was performed in patients with a wide range of disease severity recruited during routine specialist consultations. Evaluations included the Assessment of Quality of Life-8-dimension (AQoL-8D), EuroQol 5-dimension, 5-level (EQ-5D-5L), the disease-specific Inflammatory Bowel Disease Questionnaire (IBDQ), and the Work Productivity and Activity Impairment (WPAI) instrument. The 3-item Partial Mayo Score was used to assess disease severity. Health care resource utilization was assessed by chart review and patient questionnaires. Results: In 175 patients, mean (SD) AQoL-8D and EQ-5D-5L scores were greater for patients in remission (0.80 [0.19] and 0.81 [0.18], respectively) than for patients with active disease (0.70 [0.20] and 0.72 [0.19], respectively, both Ps.

UR - http://www.sciencedirect.com/science/article/pii/S1873994613004066

U2 - 10.1016/j.crohns.2013.11.017

DO - 10.1016/j.crohns.2013.11.017

M3 - Article

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SP - 598

EP - 606

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

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ER -