TY - JOUR
T1 - Relationship between compressive loading and ECM changes in tendons
AU - Docking, Sean
AU - Samiric, Tom
AU - Rio, Ebonie
AU - Purdam, Craig
AU - Cook, Jillianne Leigh
PY - 2013
Y1 - 2013
N2 - Tendons are designed to absorb and transfer large amounts of tensile load. The well organised, strong yet flexible, extracellular matrix allows for this function. Many tendons are also subject to compressive loads, such as at the entheses, as the tendon wraps around bony protuberances or from internal compression during tensile loading or twisting. Tendinopathy, the clinical syndrome of pain and dysfunction in a tendon is usually the result of overload. However, it is not only the tensile overload that should be considered, as it has been shown that compressive loads change tendon structure and that combination loads can induce tendon pathology. This review summarises how load is detected by the tenocytes, how they respond to compressive load and the resulting extracellular matrix changes that occur. Understanding the effect of compression on tendon structure and function may provide directions for future matrix based interventions.
AB - Tendons are designed to absorb and transfer large amounts of tensile load. The well organised, strong yet flexible, extracellular matrix allows for this function. Many tendons are also subject to compressive loads, such as at the entheses, as the tendon wraps around bony protuberances or from internal compression during tensile loading or twisting. Tendinopathy, the clinical syndrome of pain and dysfunction in a tendon is usually the result of overload. However, it is not only the tensile overload that should be considered, as it has been shown that compressive loads change tendon structure and that combination loads can induce tendon pathology. This review summarises how load is detected by the tenocytes, how they respond to compressive load and the resulting extracellular matrix changes that occur. Understanding the effect of compression on tendon structure and function may provide directions for future matrix based interventions.
U2 - 10.11138/mltj/2013.3.1.007
DO - 10.11138/mltj/2013.3.1.007
M3 - Article
C2 - 23885340
VL - 3
SP - 7
EP - 11
JO - Muscle, Ligaments and Tendons Journal (MLTJ)
JF - Muscle, Ligaments and Tendons Journal (MLTJ)
SN - 2240-4554
IS - 1
ER -