@article{29d9c6b0deed44138ec81904b72da7cb,
title = "Relationship between circulating lipids and cytokines in metastatic castration‐resistant prostate cancer",
abstract = "Circulating lipids or cytokines are associated with prognosis in metastatic castration-resistant prostate cancer (mCRPC). This study aimed to understand the interactions between lipid metabolism and immune response in mCRPC by investigating the relationship between the plasma lipidome and cytokines. Plasma samples from two independent cohorts of men with mCRPC (n = 146, 139) having life‐prolonging treatments were subjected to lipidomic and cytokine profiling (290, 763 lipids; 40 cytokines). Higher baseline levels of sphingolipids, including ceramides, were consistently associated with shorter overall survival in both cohorts, whereas the associations of cytokines with overall survival were inconsistent. Increasing levels of IL6, IL8, CXCL16, MPIF1, and YKL40 correlated with increasing levels of ceramide in both cohorts. Men with a poor prognostic 3‐ lipid signature at baseline had a shorter time to radiographic progression (poorer treatment response) if their lipid profile at progression was similar to that at baseline, or their cytokine profile at progression differed to that at baseline. In conclusion, baseline levels of circulating lipids were more consistent as prognostic biomarkers than cytokines. The correlation between circulating ceramides and cytokines suggests the regulation of immune responses by ceramides. The association of treatment response with the change in lipid profiles warrants further research into metabolic interventions.",
keywords = "Biomarkers, Circulating lipids, Cytokines, Lipidomic, Metastatic castration‐resistant prostate cancer",
author = "Hui-Ming Lin and Nicole Yeung and Hastings, {Jordan F.} and Croucher, {David R.} and Kevin Huynh and Meikle, {Thomas G.} and Mellett, {Natalie A.} and Kwan, {Edmond M.} and Davis, {Ian D.} and Ben Tran and Mahon, {Kate L.} and Alison Zhang and Stockler, {Martin R.} and Karen Briscoe and Gavin Marx and Patricia Bastick and Crumbaker, {Megan L.} and Joshua, {Anthony M.} and Azad, {Arun A.} and Meikle, {Peter J.} and Horvath, {Lisa G.}",
note = "Funding Information: Funding: This research was funded by National Health and Medical Research Council of Australia (GNT0614296 to L.G.H.); the Cancer Institute New South Wales (10/TPG/1‐04 & 2018/TPG001 to L.G.H.); the Australian Prostate Cancer Research Centre—New South Wales; the Australian Department of Health and Aging; the Cancer Council New South Wales (PG 10‐01 to L.G.H.); the Victorian Government{\textquoteright}s Operational Infrastructure Support Program (P.J.M.); the Australian and New Zealand Urogenital and Prostate Cancer Trials Group{\textquoteright}s Noel Castan Fellowship (H.‐M.L.); and the Twin Towns Services Community Foundation (L.G.H.). The funders had no roles in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Funding Information: This research was funded by National Health and Medical Research Council of Australia (GNT0614296 to L.G.H.); the Cancer Institute New South Wales (10/TPG/1?04 & 2018/TPG001 to L.G.H.); the Australian Prostate Cancer Research Centre?New South Wales; the Australian Department of Health and Aging; the Cancer Council New South Wales (PG 10?01 to L.G.H.); the Victorian Government?s Operational Infrastructure Support Program (P.J.M.); the Australian and New Zealand Urogenital and Prostate Cancer Trials Group?s Noel Castan Fellowship (H.?M.L.); and the Twin Towns Services Community Foundation (L.G.H.). The funders had no roles in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = oct,
day = "1",
doi = "10.3390/cancers13194964",
language = "English",
volume = "13",
journal = "Cancers",
issn = "2072-6694",
publisher = "MDPI AG",
number = "19",
}
