Relação do ácido úrico com os componentes da síndrome metabólica antes e após o bypass gástrico com reconstrução em Y-de-roux em pacientes obesos mórbidos

Translated title of the contribution: Relation of uric acid with components of metabolic syndrome before and after Roux-en-Y gastric bypass in morbidly obese subjects

Ary Serpa Neto, Felipe Martin Bianco Rossi, Leonardo Guedes Moreira Valle, Gabriel Kushiyama Teixeira, Marçal Rossi

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Objective: The purpose of the study was to investigate the prevalence of hyperuricemia in morbidly obese subjects before and after Roux-en-Y gastric bypass (RYGBP) and its relationship with metabolic syndrome abnormalities. Subjects and method: We evaluated 420 morbidly obese patients. Pre and postoperative (8 months after RYGBP) blood samples were drawn. Obese patients underwent laparoscopic RYGBP and after eight months all the tests were repeated. Results: The overall prevalence of hyperuricemia was 34.28%. Hyperuricemia was more common in men than in women (51.72 vs. 29.72%; p = 0.0002). Men with hyperuricemia were more likely to have diabetes (p = 0.034) and more elevated fasting plasma glucose levels (p = 0.027). Women with hyperuricemia were more likely to have hypertension (p = 0.003), metabolic syndrome (p = 0.001), elevated triglycerides (p = 0.001) and GGT (p = 0.009), and decreased HDL (p = 0.011). After surgery, uric acid levels decreased from 5.60 ± 1.28 to 4.23 ± 1.20 (p < 0.0001). The prevalence of hyperuricemia decreased from 33.6% to 6.4% (p < 0.0001), in men from 48.3% to 17.2% (p < 0.0001) and in women from 29.7% to 3.6% (p < 0.0001). Conclusion: Concentrations of uric acid were associated with the prevalence of metabolic abnormalities in this sample of morbidly obese patients. Also, weight loss after RYGBP can reduce uric acid levels and the prevalence of hyperuricemia.

Translated title of the contributionRelation of uric acid with components of metabolic syndrome before and after Roux-en-Y gastric bypass in morbidly obese subjects
Original languagePortuguese
Pages (from-to)38-45
Number of pages8
JournalArquivos Brasileiros de Endocrinologia e Metabologia
Volume55
Issue number1
DOIs
Publication statusPublished - Feb 2011
Externally publishedYes

Keywords

  • Bariatric surgery
  • Metabolic syndrome
  • Uric acid

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