Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

Raelene J. Grumont, Ian J. Rourke, Steve Gerondakis

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Abstract

In response to different extracellular signals, Rel/NF-κB transcription factors are critical regulators of apoptosis in a variety of cell types. Here we show that in normal B and T cells, expression of the Bcl-2 prosurvival homolog, A1, is rapidly induced in a Rel-dependent manner by mitogens. In B- cell lines derived from c-rel(-/-) mice, which like primary cells lacking Rel undergo apoptosis in response to antigen receptor ligation, constitutive expression of an A1 transgene inhibits this pathway to cell death. These findings are the first to show that Rel/NF-κB regulates physiologically the expression of a Bcl-2-like protein that is critical for the control of cell survival during lymphocyte activation.

Original languageEnglish
Pages (from-to)400-411
Number of pages12
JournalGenes & Development
Volume13
Issue number4
DOIs
Publication statusPublished - 15 Feb 1999
Externally publishedYes

Keywords

  • A1
  • Apoptosis
  • Lymphocyte
  • Mitogenesis
  • Rel/NF-κB

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