Abstract
The identification of stem cells and growth factors as well as the development of biomaterials hold great promise for regenerative medicine applications. However, the therapeutic efficacy of regenerative therapies can be greatly influenced by the host immune system, which plays a pivotal role during tissue repair and regeneration. Therefore, understanding how the immune system modulates tissue healing is critical to design efficient regenerative strategies. While the innate immune system is well known to be involved in the tissue healing process, the adaptive immune system has recently emerged as a key player. T-cells, in particular, regulatory T-cells (Treg), have been shown to promote repair and regeneration of various organ systems. In this review, we discuss the mechanisms by which Treg participate in the repair and regeneration of skeletal and heart muscle, skin, lung, bone, and the central nervous system.
| Original language | English |
|---|---|
| Article number | 585 |
| Number of pages | 11 |
| Journal | Frontiers in Immunology |
| Volume | 9 |
| DOIs | |
| Publication status | Published - 23 Mar 2018 |
Keywords
- CD4 regulatory T-cells
- Heart regeneration
- Macrophages
- Stem cells
- Tissue repair and regeneration
Cite this
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Regulatory T-cells : Potential regulator of tissue repair and regeneration. / Li, Jiatao; Tan, Jean; Martino, Mikaël M.; Lui, Kathy O.
In: Frontiers in Immunology, Vol. 9, 585, 23.03.2018.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Regulatory T-cells
T2 - Potential regulator of tissue repair and regeneration
AU - Li, Jiatao
AU - Tan, Jean
AU - Martino, Mikaël M.
AU - Lui, Kathy O.
PY - 2018/3/23
Y1 - 2018/3/23
N2 - The identification of stem cells and growth factors as well as the development of biomaterials hold great promise for regenerative medicine applications. However, the therapeutic efficacy of regenerative therapies can be greatly influenced by the host immune system, which plays a pivotal role during tissue repair and regeneration. Therefore, understanding how the immune system modulates tissue healing is critical to design efficient regenerative strategies. While the innate immune system is well known to be involved in the tissue healing process, the adaptive immune system has recently emerged as a key player. T-cells, in particular, regulatory T-cells (Treg), have been shown to promote repair and regeneration of various organ systems. In this review, we discuss the mechanisms by which Treg participate in the repair and regeneration of skeletal and heart muscle, skin, lung, bone, and the central nervous system.
AB - The identification of stem cells and growth factors as well as the development of biomaterials hold great promise for regenerative medicine applications. However, the therapeutic efficacy of regenerative therapies can be greatly influenced by the host immune system, which plays a pivotal role during tissue repair and regeneration. Therefore, understanding how the immune system modulates tissue healing is critical to design efficient regenerative strategies. While the innate immune system is well known to be involved in the tissue healing process, the adaptive immune system has recently emerged as a key player. T-cells, in particular, regulatory T-cells (Treg), have been shown to promote repair and regeneration of various organ systems. In this review, we discuss the mechanisms by which Treg participate in the repair and regeneration of skeletal and heart muscle, skin, lung, bone, and the central nervous system.
KW - CD4 regulatory T-cells
KW - Heart regeneration
KW - Macrophages
KW - Stem cells
KW - Tissue repair and regeneration
UR - http://www.scopus.com/inward/record.url?scp=85044438875&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2018.00585
DO - 10.3389/fimmu.2018.00585
M3 - Review Article
VL - 9
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 585
ER -