Regulatory T-cells: Potential regulator of tissue repair and regeneration

Jiatao Li, Jean Tan, Mikaël M. Martino, Kathy O. Lui

Research output: Contribution to journalReview ArticleResearchpeer-review

65 Citations (Scopus)

Abstract

The identification of stem cells and growth factors as well as the development of biomaterials hold great promise for regenerative medicine applications. However, the therapeutic efficacy of regenerative therapies can be greatly influenced by the host immune system, which plays a pivotal role during tissue repair and regeneration. Therefore, understanding how the immune system modulates tissue healing is critical to design efficient regenerative strategies. While the innate immune system is well known to be involved in the tissue healing process, the adaptive immune system has recently emerged as a key player. T-cells, in particular, regulatory T-cells (Treg), have been shown to promote repair and regeneration of various organ systems. In this review, we discuss the mechanisms by which Treg participate in the repair and regeneration of skeletal and heart muscle, skin, lung, bone, and the central nervous system.

Original languageEnglish
Article number585
Number of pages11
JournalFrontiers in Immunology
Volume9
DOIs
Publication statusPublished - 23 Mar 2018

Keywords

  • CD4 regulatory T-cells
  • Heart regeneration
  • Macrophages
  • Stem cells
  • Tissue repair and regeneration

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