Regulatory T cells in transplantation

Herman Waldmann; Tse Ching Chen; Luis Graca; Elizabeth Adams; Stephen Daley; Stephen Cobbold; Paul J. Fairchild

doi:10.1016/j.smim.2006.01.010

Regulatory T cells in transplantation

Herman Waldmann, Tse Ching Chen, Luis Graca, Elizabeth Adams, Stephen Daley, Stephen Cobbold, Paul J. Fairchild

Research output: Contribution to journal › Review Article › Research › peer-review

68 Citations (Scopus)

Abstract

Our ability to harness tolerance mechanisms will have a major impact in organ transplantation. It should enable drug minimization, and eventually, the elimination of all immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the selective vaccination of T cells that prevent graft rejection. Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection.

Original language	English
Pages (from-to)	111-119
Number of pages	9
Journal	Seminars in Immunology
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/j.smim.2006.01.010
Publication status	Published - 1 Apr 2006
Externally published	Yes

Keywords

Infectious tolerance
Privilege
Regulation
Regulatory T cell
Tolerance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.smim.2006.01.010

Cite this

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abstract = "Our ability to harness tolerance mechanisms will have a major impact in organ transplantation. It should enable drug minimization, and eventually, the elimination of all immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the selective vaccination of T cells that prevent graft rejection. Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection.",

keywords = "Infectious tolerance, Privilege, Regulation, Regulatory T cell, Tolerance",

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AU - Waldmann, Herman

AU - Chen, Tse Ching

AU - Graca, Luis

AU - Adams, Elizabeth

AU - Daley, Stephen

AU - Cobbold, Stephen

AU - Fairchild, Paul J.

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Our ability to harness tolerance mechanisms will have a major impact in organ transplantation. It should enable drug minimization, and eventually, the elimination of all immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the selective vaccination of T cells that prevent graft rejection. Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection.

AB - Our ability to harness tolerance mechanisms will have a major impact in organ transplantation. It should enable drug minimization, and eventually, the elimination of all immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the selective vaccination of T cells that prevent graft rejection. Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection.

KW - Infectious tolerance

KW - Privilege

KW - Regulation

KW - Regulatory T cell

KW - Tolerance

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U2 - 10.1016/j.smim.2006.01.010

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M3 - Review Article

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EP - 119

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

IS - 2

ER -

Regulatory T cells in transplantation

Abstract

Keywords

UN SDGs

Access to Document

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