Regulatory T cells in transplantation

Herman Waldmann, Tse Ching Chen, Luis Graca, Elizabeth Adams, Stephen Daley, Stephen Cobbold, Paul J. Fairchild

Research output: Contribution to journalReview ArticleResearchpeer-review

66 Citations (Scopus)

Abstract

Our ability to harness tolerance mechanisms will have a major impact in organ transplantation. It should enable drug minimization, and eventually, the elimination of all immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the selective vaccination of T cells that prevent graft rejection. Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection.

Original languageEnglish
Pages (from-to)111-119
Number of pages9
JournalSeminars in Immunology
Volume18
Issue number2
DOIs
Publication statusPublished - 1 Apr 2006
Externally publishedYes

Keywords

  • Infectious tolerance
  • Privilege
  • Regulation
  • Regulatory T cell
  • Tolerance

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