Abstract
Our ability to harness tolerance mechanisms will have a major impact in organ transplantation. It should enable drug minimization, and eventually, the elimination of all immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the selective vaccination of T cells that prevent graft rejection. Once regulation is established, the continued supply of graft antigens should empower T cell regulation to become the dominant natural mechanism to prevent graft rejection.
Original language | English |
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Pages (from-to) | 111-119 |
Number of pages | 9 |
Journal | Seminars in Immunology |
Volume | 18 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Apr 2006 |
Externally published | Yes |
Keywords
- Infectious tolerance
- Privilege
- Regulation
- Regulatory T cell
- Tolerance