TY - JOUR
T1 - Regulatory T-cells
T2 - Immunomodulators in health and disease
AU - Scalzo, Karen
AU - Plebanski, Magdalena
AU - Apostolopoulos, Vasso
PY - 2006/8
Y1 - 2006/8
N2 - Regulation of immune responses is crucial in order to maintain immunological self-tolerance. This is maintained in the periphery by a number of cell types that have the capacity to control and regulate immune responses, thus preventing reactivity to self while monitoring appropriate, non-exuberant responses to non-self-antigens. The various mechanisms of regulation will be discussed in this review together with how this knowledge could be used to develop better drugs and treatments for various diseases.
AB - Regulation of immune responses is crucial in order to maintain immunological self-tolerance. This is maintained in the periphery by a number of cell types that have the capacity to control and regulate immune responses, thus preventing reactivity to self while monitoring appropriate, non-exuberant responses to non-self-antigens. The various mechanisms of regulation will be discussed in this review together with how this knowledge could be used to develop better drugs and treatments for various diseases.
KW - CD4+CD25+regulatory cells
KW - Immuno-modulatory drugs
KW - Th3
KW - Tr1
UR - http://www.scopus.com/inward/record.url?scp=33748316568&partnerID=8YFLogxK
U2 - 10.2174/156802606778194262
DO - 10.2174/156802606778194262
M3 - Review Article
C2 - 17017955
AN - SCOPUS:33748316568
SN - 1568-0266
VL - 6
SP - 1759
EP - 1768
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
IS - 16
ER -