Regulatory T-cells: Immunomodulators in health and disease

Karen Scalzo, Magdalena Plebanski, Vasso Apostolopoulos

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)


Regulation of immune responses is crucial in order to maintain immunological self-tolerance. This is maintained in the periphery by a number of cell types that have the capacity to control and regulate immune responses, thus preventing reactivity to self while monitoring appropriate, non-exuberant responses to non-self-antigens. The various mechanisms of regulation will be discussed in this review together with how this knowledge could be used to develop better drugs and treatments for various diseases.

Original languageEnglish
Pages (from-to)1759-1768
Number of pages10
JournalCurrent Topics in Medicinal Chemistry
Issue number16
Publication statusPublished - Aug 2006
Externally publishedYes


  • CD4+CD25+regulatory cells
  • Immuno-modulatory drugs
  • Th3
  • Tr1

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