TY - JOUR
T1 - Regulatory landscape of the hox transcriptome
AU - Casaca, A. N.A.
AU - Hauswirth, Gabriel M.
AU - Bildsoe, Heidi
AU - Mallo, Moisés
AU - McGlinn, Edwina
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks.
AB - Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks.
KW - Hox gene
KW - LncRNA
KW - MicroRNA
KW - Polycistronic
KW - Post-transcriptional regulation
UR - http://www.scopus.com/inward/record.url?scp=85058800570&partnerID=8YFLogxK
U2 - 10.1387/ijdb.180270em
DO - 10.1387/ijdb.180270em
M3 - Article
C2 - 30604839
AN - SCOPUS:85058800570
SN - 0214-6282
VL - 62
SP - 693
EP - 704
JO - International Journal of Developmental Biology
JF - International Journal of Developmental Biology
IS - 11-12
M1 - 62
ER -