Regulatory landscape of the hox transcriptome

A. N.A. Casaca, Gabriel M. Hauswirth, Heidi Bildsoe, Moisés Mallo, Edwina McGlinn

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4 Citations (Scopus)

Abstract

Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks.

Original languageEnglish
Article number62
Pages (from-to)693-704
Number of pages12
JournalInternational Journal of Developmental Biology
Volume62
Issue number11-12
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Hox gene
  • LncRNA
  • MicroRNA
  • Polycistronic
  • Post-transcriptional regulation

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