TY - JOUR
T1 - Regulatory constraints in the generation and differentiation of IgE-expressing B cells
AU - Yang, Zhiyong
AU - Robinson, Marcus J.
AU - Allen, Christopher D.C.
PY - 2014/6
Y1 - 2014/6
N2 - B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE+) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE+ B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE+ B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE+ B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.
AB - B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE+) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE+ B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE+ B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE+ B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.
UR - http://www.scopus.com/inward/record.url?scp=84895942390&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2014.02.001
DO - 10.1016/j.coi.2014.02.001
M3 - Review Article
C2 - 24632082
AN - SCOPUS:84895942390
VL - 28
SP - 64
EP - 70
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
ER -