Regulatory constraints in the generation and differentiation of IgE-expressing B cells

Zhiyong Yang, Marcus J. Robinson, Christopher D.C. Allen

Research output: Contribution to journalReview ArticleResearchpeer-review

22 Citations (Scopus)

Abstract

B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE+) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE+ B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE+ B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE+ B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalCurrent Opinion in Immunology
Volume28
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

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