Abstract
B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE+) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE+ B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE+ B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE+ B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.
| Original language | English |
|---|---|
| Pages (from-to) | 64-70 |
| Number of pages | 7 |
| Journal | Current Opinion in Immunology |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 |
| Externally published | Yes |
Cite this
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Regulatory constraints in the generation and differentiation of IgE-expressing B cells. / Yang, Zhiyong; Robinson, Marcus J.; Allen, Christopher D C.
In: Current Opinion in Immunology, Vol. 28, No. 1, 2014, p. 64-70.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Regulatory constraints in the generation and differentiation of IgE-expressing B cells
AU - Yang, Zhiyong
AU - Robinson, Marcus J.
AU - Allen, Christopher D C
PY - 2014
Y1 - 2014
N2 - B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE+) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE+ B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE+ B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE+ B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.
AB - B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE+) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE+ B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE+ B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE+ B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.
UR - http://www.scopus.com/inward/record.url?scp=84895942390&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2014.02.001
DO - 10.1016/j.coi.2014.02.001
M3 - Review Article
VL - 28
SP - 64
EP - 70
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 1
ER -