Regulation of second messenger systems and intracellular pathways

Stefania Merighi; Carolina Simioni; Rob Lane; Adriaan P IJzerman

doi:10.1007/978-90-481-3144-0_4

Regulation of second messenger systems and intracellular pathways

Stefania Merighi, Carolina Simioni, Rob Lane, Adriaan P IJzerman

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

5 Citations (Scopus)

Abstract

The A₃ adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell growth, survival, death and differentiation. Interestingly, the A₃ receptor has recently been linked to the hypoxia-inducible factor 1 (HIF-1), the main transcription factor regulating the cellular responses to hypoxia. The focus of this chapter centres on downstream mediators of A₃ adenosine receptor signaling.

Original language	English
Title of host publication	A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics
Publisher	Springer
Pages	61-73
Number of pages	13
ISBN (Print)	9789048131433
DOIs	https://doi.org/10.1007/978-90-481-3144-0_4
Publication status	Published - 2010
Externally published	Yes

Keywords

Akt
G-protein
HIF-1
MAPK
signal transduction

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10.1007/978-90-481-3144-0_4

Cite this

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T1 - Regulation of second messenger systems and intracellular pathways

AU - Merighi, Stefania

AU - Simioni, Carolina

AU - Lane, Rob

AU - IJzerman, Adriaan P

PY - 2010

Y1 - 2010

N2 - The A3 adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell growth, survival, death and differentiation. Interestingly, the A3 receptor has recently been linked to the hypoxia-inducible factor 1 (HIF-1), the main transcription factor regulating the cellular responses to hypoxia. The focus of this chapter centres on downstream mediators of A3 adenosine receptor signaling.

AB - The A3 adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell growth, survival, death and differentiation. Interestingly, the A3 receptor has recently been linked to the hypoxia-inducible factor 1 (HIF-1), the main transcription factor regulating the cellular responses to hypoxia. The focus of this chapter centres on downstream mediators of A3 adenosine receptor signaling.

KW - Akt

KW - G-protein

KW - HIF-1

KW - MAPK

KW - signal transduction

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SN - 9789048131433

SP - 61

EP - 73

BT - A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics

PB - Springer

ER -

Regulation of second messenger systems and intracellular pathways

Abstract

Keywords

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