Regulation of second messenger systems and intracellular pathways

Stefania Merighi, Carolina Simioni, Rob Lane, Adriaan P IJzerman

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

4 Citations (Scopus)


The A3 adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell growth, survival, death and differentiation. Interestingly, the A3 receptor has recently been linked to the hypoxia-inducible factor 1 (HIF-1), the main transcription factor regulating the cellular responses to hypoxia. The focus of this chapter centres on downstream mediators of A3 adenosine receptor signaling.

Original languageEnglish
Title of host publicationA3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics
Number of pages13
ISBN (Print)9789048131433
Publication statusPublished - 2010
Externally publishedYes


  • Akt
  • G-protein
  • HIF-1
  • MAPK
  • signal transduction

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