Regulation of Pancreatic β-Cell Function by the NPY System

Chieh Hsin Yang, Danise Ann Onda, Jonathan S. Oakhill, John W. Scott, Sandra Galic, Kim Loh

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Abstract

The neuropeptide Y (NPY) system has been recognized as one of the most critical molecules in the regulation of energy homeostasis and glucose metabolism. Abnormal levels of NPY have been shown to contribute to the development of metabolic disorders including obesity, cardiovascular diseases, and diabetes. NPY centrally promotes feeding and reduces energy expenditure, while the other family members, peptide YY (PYY) and pancreatic polypeptide (PP), mediate satiety. New evidence has uncovered additional functions for these peptides that go beyond energy expenditure and appetite regulation, indicating a more extensive function in controlling other physiological functions. In this review, we will discuss the role of the NPY system in the regulation of pancreatic β-cell function and its therapeutic implications for diabetes.

Original languageEnglish
Article numberbqab070
Number of pages8
JournalEndocrinology
Volume162
Issue number8
DOIs
Publication statusPublished - Aug 2021
Externally publishedYes

Keywords

  • insulin secretion
  • neuropeptide Y
  • pancreatic polypeptide
  • pancreatic β-cell
  • peptide YY
  • type 2 diabetes

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