Regulation of p70s6k/p85s6k and its role in the cell cycle.

R. B. Pearson, G. Thomas

Research output: Contribution to journalReview ArticleResearchpeer-review

42 Citations (Scopus)

Abstract

Two to three-fold increases in the rate of protein synthesis are required both to enter the G1 phase of the cell cycle from G0 and to proceed to S phase in response to growth factors and mitogens. This increase is in part regulated via multiple phosphorylation of the 40S ribosomal protein S6 by the mitogen-stimulated p70s6k/p85s6k. At the protein synthesis level this event appears to be involved in specifically increasing the efficiency of translation of a family of essential mRNAs containing a polypyrimidine tract at their 5' transcriptional start site. The activation of p70s6k/p85s6k and maintenance of its activity throughout G1 is controlled via multiple phosphorylation events mediated by a complex signalling network acting on distinct sets of phosphorylation sites.

Original languageEnglish
Pages (from-to)21-32
Number of pages12
JournalProgress in Cell Cycle Research
Volume1
Publication statusPublished - 1 Dec 1995
Externally publishedYes

Cite this

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title = "Regulation of p70s6k/p85s6k and its role in the cell cycle.",
abstract = "Two to three-fold increases in the rate of protein synthesis are required both to enter the G1 phase of the cell cycle from G0 and to proceed to S phase in response to growth factors and mitogens. This increase is in part regulated via multiple phosphorylation of the 40S ribosomal protein S6 by the mitogen-stimulated p70s6k/p85s6k. At the protein synthesis level this event appears to be involved in specifically increasing the efficiency of translation of a family of essential mRNAs containing a polypyrimidine tract at their 5' transcriptional start site. The activation of p70s6k/p85s6k and maintenance of its activity throughout G1 is controlled via multiple phosphorylation events mediated by a complex signalling network acting on distinct sets of phosphorylation sites.",
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Regulation of p70s6k/p85s6k and its role in the cell cycle. / Pearson, R. B.; Thomas, G.

In: Progress in Cell Cycle Research, Vol. 1, 01.12.1995, p. 21-32.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Regulation of p70s6k/p85s6k and its role in the cell cycle.

AU - Pearson, R. B.

AU - Thomas, G.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - Two to three-fold increases in the rate of protein synthesis are required both to enter the G1 phase of the cell cycle from G0 and to proceed to S phase in response to growth factors and mitogens. This increase is in part regulated via multiple phosphorylation of the 40S ribosomal protein S6 by the mitogen-stimulated p70s6k/p85s6k. At the protein synthesis level this event appears to be involved in specifically increasing the efficiency of translation of a family of essential mRNAs containing a polypyrimidine tract at their 5' transcriptional start site. The activation of p70s6k/p85s6k and maintenance of its activity throughout G1 is controlled via multiple phosphorylation events mediated by a complex signalling network acting on distinct sets of phosphorylation sites.

AB - Two to three-fold increases in the rate of protein synthesis are required both to enter the G1 phase of the cell cycle from G0 and to proceed to S phase in response to growth factors and mitogens. This increase is in part regulated via multiple phosphorylation of the 40S ribosomal protein S6 by the mitogen-stimulated p70s6k/p85s6k. At the protein synthesis level this event appears to be involved in specifically increasing the efficiency of translation of a family of essential mRNAs containing a polypyrimidine tract at their 5' transcriptional start site. The activation of p70s6k/p85s6k and maintenance of its activity throughout G1 is controlled via multiple phosphorylation events mediated by a complex signalling network acting on distinct sets of phosphorylation sites.

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EP - 32

JO - Progress in Cell Cycle Research

JF - Progress in Cell Cycle Research

SN - 1087-2957

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