Regulation of nucleocytoplasmic trafficking of viral proteins: An integral role in pathogenesis?

Alex Fulcher, David Jans

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Abstract

Signal-dependent targeting of proteins into and out of the nucleus is mediated by members of the importin (IMP) family of transport receptors, which recognise targeting signals within a cargo protein and mediate passage through the nuclear envelope-embedded nuclear pore complexes. Regulation of this process is paramount to processes such as cell division and differentiation, but is also critically important for viral replication and pathogenesis; phosphorylation appears to play a major role in regulating viral protein nucleocytoplasmic trafficking, along with other posttranslational modifications. This review focuses on viral proteins that utilise the host cell IMP machinery in order to traffic into/out of the nucleus, and in particular those where trafficking is critical to viral replication and/or pathogenesis, such as simian virus SV40 large tumour antigen (T-ag), human papilloma virus E1 protein, human cytomegalovirus processivity factor ppUL44, and various gene products from RNA viruses such as Rabies. Understanding of the mechanisms regulating viral protein nucleocytoplasmic trafficking is paramount to the future development of urgently needed specific and effective anti-viral therapeutics. This article is part of a Special Issue entitled: Regulation of Signalling and Cellular Fate through Modulation of Nuclear Protein Import.
Original languageEnglish
Pages (from-to)2176 - 2190
Number of pages15
JournalBiochimica et Biophysica Acta: international journal of biochemistry and biophysics
Volume1813
Issue number12
DOIs
Publication statusPublished - 2011

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