Regulation of murine natural killer cell commitment

Nicholas D. Huntington, Stephen L. Nutt, Sebastian Carotta

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Abstract

Natural killer (NK) cells can derive from the same precursors as B andT cells, however, to achieve lineage specificity, several transcription factors need to be activated or annulled. While a few important transcription factors have been identified for NK genesis the mechanisms of how this is achieved is far from resolved. Adding to the complexity of this, NK cells are found and potentially develop in diverse locations in vivo and it remains to be addressed if a common NK cell precursor seeds diverse niches and how transcription factors may differentially regulate NKcell commitment in distinct microenvironments. Here we will summarize some recent findings in NKcell commitment and discuss how a NKcell transcriptional network might be organized, while addressing some misconceptions and anomalies along the way.

Original languageEnglish
JournalFrontiers in Immunology
Volume4
DOIs
Publication statusPublished - 28 Feb 2013
Externally publishedYes

Keywords

  • Development
  • Differentiation
  • ID2
  • Innate lymphocytes
  • Natural killer cells
  • NFIL3
  • Pre-pro NK cells
  • Transcription factors

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