Regulation of MDR1 gene expression: Emerging concepts

Phillip Kantharidis, Sam El-Osta, Michelle De Silva, Grace Lee, Xiu F. Hu, John Zalcberg

Research output: Contribution to journalReview ArticleResearchpeer-review

25 Citations (Scopus)


Drug resistance genes, such as MDR1, involved in drug efflux, and their regulation have been the subject of intense research efforts in the past 10 years. Many factors and cellular signalling pathways play a role in the regulation of MDR1 gene expression. Commonly used chemotherapeutic agents activate in vitro and in vivo general stress response pathways, potential targets of which include MDR1 and other drug resistance genes. The contribution of these agents to the emergence of drug-resistant tumour cells is of concern. Recent evidence points to a role for the epigenetic regulation of MDR1 gene expression. The identification of key components in the DNA methylation/chromatin system of gene regulation may in time lead to more informed and targeted approaches to treating drug-resistant tumours. (C) 2000 Harcourt Publishers Ltd.

Original languageEnglish
Pages (from-to)99-108
Number of pages10
JournalDrug Resistance Updates
Issue number2
Publication statusPublished - Apr 2000
Externally publishedYes

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