Regulation of intestinal stem cells by Wnt and Notch signalling

Katja Horvay, Helen E. Abud

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

10 Citations (Scopus)

Abstract

The mammalian intestine is lined by an epithelial cell layer that is constantly renewed via a population of stem cells that reside in a specialised niche within intestinal crypts. The recent development of tools that permit genetic manipulation and lineage tracing of cells in vivo combined with culture methods in vitro has made the intestine particularly amenable for the study of signals that regulate stem cell function. Both Wnt and Notch signalling are critical regulators of stem cell fate. Gene knockout and transgenic expression analysis combined with meticulous analysis of lineage tracing and molecular characterisation has contributed to the definition of the mechanisms by which these pathways act during normal homeostasis and in disease states. 

Original languageEnglish
Title of host publicationTranscriptional and Translational Regulation of Stem Cells
EditorsGary Hime, Helen Abud
PublisherSpringer
Pages175-186
Number of pages12
Volume786
ISBN (Electronic)9789400766211
ISBN (Print)9789400766204
DOIs
Publication statusPublished - 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume786
ISSN (Print)00652598

Keywords

  • Crypt
  • Hes1
  • Lgr5
  • Olfm4
  • β-catenin

Cite this

Horvay, K., & Abud, H. E. (2013). Regulation of intestinal stem cells by Wnt and Notch signalling. In G. Hime, & H. Abud (Eds.), Transcriptional and Translational Regulation of Stem Cells (Vol. 786, pp. 175-186). (Advances in Experimental Medicine and Biology; Vol. 786). Springer. https://doi.org/10.1007/978-94-007-6621-1_10