Regulation of immune responses by histone deacetylase inhibitors

Paul V Licciardi, Tom C. Karagiannis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Both genetic and epigenetic factors are important regulators of the immune system. There is an increasing body of evidence attesting to epigenetic modifications that influence the development of distinct innate and adaptive immune response cells. Chromatin remodelling via acetylation, methylation, phosphorylation, and ubiquitination of histone proteins as well as DNA, methylation is epigenetic mechanisms by which immune gene expression can be controlled. In this paper, we will discuss the role of epigenetics in the regulation of host immunity, with particular emphasis on histone deacetylase inhibitors. In particular, the role of HDAC inhibitors as a new class of immunomodulatory therapeutics will also be reviewed.
Original languageEnglish
Article number690901
Number of pages10
JournalISRN Hematology
Volume2012
DOIs
Publication statusPublished - 2012
Externally publishedYes

Cite this