Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase

growth factors and beyond

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout mouse studies have shown the importance of SHIP-1 in various immune cell subsets and have revealed a range of immune-mediated pathologies that are engendered due to loss of SHIP-1’s regulatory activity, impelling investigations into the role of SHIP-1 in human disease. In this review, we provide an overview of the literature relating to the role of SHIP-1 in hematopoietic cell signaling and function, we summarize recent reports that highlight the dysregulation of the SHIP-1 pathway in cancers, autoimmune disorders and inflammatory diseases, and lastly we discuss the importance of SHIP-1 in restraining myeloid growth factor signaling.

Original languageEnglish
Pages (from-to)213-231
Number of pages19
JournalGrowth Factors
Volume36
Issue number5-6
DOIs
Publication statusPublished - 2 Nov 2018

Keywords

  • G-CSF
  • hematopoietic cell signaling
  • inflammatory disease
  • negative regulator
  • SHIP-1

Cite this

@article{c6feb24550d2407ca1e46ce902436b1c,
title = "Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase: growth factors and beyond",
abstract = "SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout mouse studies have shown the importance of SHIP-1 in various immune cell subsets and have revealed a range of immune-mediated pathologies that are engendered due to loss of SHIP-1’s regulatory activity, impelling investigations into the role of SHIP-1 in human disease. In this review, we provide an overview of the literature relating to the role of SHIP-1 in hematopoietic cell signaling and function, we summarize recent reports that highlight the dysregulation of the SHIP-1 pathway in cancers, autoimmune disorders and inflammatory diseases, and lastly we discuss the importance of SHIP-1 in restraining myeloid growth factor signaling.",
keywords = "G-CSF, hematopoietic cell signaling, inflammatory disease, negative regulator, SHIP-1",
author = "Hibbs, {Margaret L.} and Raftery, {April L.} and Evelyn Tsantikos",
year = "2018",
month = "11",
day = "2",
doi = "10.1080/08977194.2019.1569649",
language = "English",
volume = "36",
pages = "213--231",
journal = "Growth Factors",
issn = "0897-7194",
publisher = "Taylor & Francis",
number = "5-6",

}

Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase : growth factors and beyond. / Hibbs, Margaret L.; Raftery, April L.; Tsantikos, Evelyn.

In: Growth Factors, Vol. 36, No. 5-6, 02.11.2018, p. 213-231.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase

T2 - growth factors and beyond

AU - Hibbs, Margaret L.

AU - Raftery, April L.

AU - Tsantikos, Evelyn

PY - 2018/11/2

Y1 - 2018/11/2

N2 - SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout mouse studies have shown the importance of SHIP-1 in various immune cell subsets and have revealed a range of immune-mediated pathologies that are engendered due to loss of SHIP-1’s regulatory activity, impelling investigations into the role of SHIP-1 in human disease. In this review, we provide an overview of the literature relating to the role of SHIP-1 in hematopoietic cell signaling and function, we summarize recent reports that highlight the dysregulation of the SHIP-1 pathway in cancers, autoimmune disorders and inflammatory diseases, and lastly we discuss the importance of SHIP-1 in restraining myeloid growth factor signaling.

AB - SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout mouse studies have shown the importance of SHIP-1 in various immune cell subsets and have revealed a range of immune-mediated pathologies that are engendered due to loss of SHIP-1’s regulatory activity, impelling investigations into the role of SHIP-1 in human disease. In this review, we provide an overview of the literature relating to the role of SHIP-1 in hematopoietic cell signaling and function, we summarize recent reports that highlight the dysregulation of the SHIP-1 pathway in cancers, autoimmune disorders and inflammatory diseases, and lastly we discuss the importance of SHIP-1 in restraining myeloid growth factor signaling.

KW - G-CSF

KW - hematopoietic cell signaling

KW - inflammatory disease

KW - negative regulator

KW - SHIP-1

UR - http://www.scopus.com/inward/record.url?scp=85061919172&partnerID=8YFLogxK

U2 - 10.1080/08977194.2019.1569649

DO - 10.1080/08977194.2019.1569649

M3 - Review Article

VL - 36

SP - 213

EP - 231

JO - Growth Factors

JF - Growth Factors

SN - 0897-7194

IS - 5-6

ER -