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Abstract
SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout mouse studies have shown the importance of SHIP-1 in various immune cell subsets and have revealed a range of immune-mediated pathologies that are engendered due to loss of SHIP-1’s regulatory activity, impelling investigations into the role of SHIP-1 in human disease. In this review, we provide an overview of the literature relating to the role of SHIP-1 in hematopoietic cell signaling and function, we summarize recent reports that highlight the dysregulation of the SHIP-1 pathway in cancers, autoimmune disorders and inflammatory diseases, and lastly we discuss the importance of SHIP-1 in restraining myeloid growth factor signaling.
| Original language | English |
|---|---|
| Pages (from-to) | 213-231 |
| Number of pages | 19 |
| Journal | Growth Factors |
| Volume | 36 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 2 Nov 2018 |
Keywords
- G-CSF
- hematopoietic cell signaling
- inflammatory disease
- negative regulator
- SHIP-1
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Projects
- 1 Finished
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G-CSF = granulocyte colony-stimulating factor: G-CSF: a pathogenic effector in chronic obstructive pulmonary disease and its comorbidities
Hibbs, M. (Primary Chief Investigator (PCI)), Anderson, G. P. (Chief Investigator (CI)) & Tsantikos, E. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/18 → 31/12/21
Project: Research