Abstract
SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout mouse studies have shown the importance of SHIP-1 in various immune cell subsets and have revealed a range of immune-mediated pathologies that are engendered due to loss of SHIP-1’s regulatory activity, impelling investigations into the role of SHIP-1 in human disease. In this review, we provide an overview of the literature relating to the role of SHIP-1 in hematopoietic cell signaling and function, we summarize recent reports that highlight the dysregulation of the SHIP-1 pathway in cancers, autoimmune disorders and inflammatory diseases, and lastly we discuss the importance of SHIP-1 in restraining myeloid growth factor signaling.
| Original language | English |
|---|---|
| Pages (from-to) | 213-231 |
| Number of pages | 19 |
| Journal | Growth Factors |
| Volume | 36 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 2 Nov 2018 |
Keywords
- G-CSF
- hematopoietic cell signaling
- inflammatory disease
- negative regulator
- SHIP-1
Cite this
}
Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase : growth factors and beyond. / Hibbs, Margaret L.; Raftery, April L.; Tsantikos, Evelyn.
In: Growth Factors, Vol. 36, No. 5-6, 02.11.2018, p. 213-231.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Regulation of hematopoietic cell signaling by SHIP-1 inositol phosphatase
T2 - growth factors and beyond
AU - Hibbs, Margaret L.
AU - Raftery, April L.
AU - Tsantikos, Evelyn
PY - 2018/11/2
Y1 - 2018/11/2
N2 - SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout mouse studies have shown the importance of SHIP-1 in various immune cell subsets and have revealed a range of immune-mediated pathologies that are engendered due to loss of SHIP-1’s regulatory activity, impelling investigations into the role of SHIP-1 in human disease. In this review, we provide an overview of the literature relating to the role of SHIP-1 in hematopoietic cell signaling and function, we summarize recent reports that highlight the dysregulation of the SHIP-1 pathway in cancers, autoimmune disorders and inflammatory diseases, and lastly we discuss the importance of SHIP-1 in restraining myeloid growth factor signaling.
AB - SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout mouse studies have shown the importance of SHIP-1 in various immune cell subsets and have revealed a range of immune-mediated pathologies that are engendered due to loss of SHIP-1’s regulatory activity, impelling investigations into the role of SHIP-1 in human disease. In this review, we provide an overview of the literature relating to the role of SHIP-1 in hematopoietic cell signaling and function, we summarize recent reports that highlight the dysregulation of the SHIP-1 pathway in cancers, autoimmune disorders and inflammatory diseases, and lastly we discuss the importance of SHIP-1 in restraining myeloid growth factor signaling.
KW - G-CSF
KW - hematopoietic cell signaling
KW - inflammatory disease
KW - negative regulator
KW - SHIP-1
UR - http://www.scopus.com/inward/record.url?scp=85061919172&partnerID=8YFLogxK
U2 - 10.1080/08977194.2019.1569649
DO - 10.1080/08977194.2019.1569649
M3 - Review Article
VL - 36
SP - 213
EP - 231
JO - Growth Factors
JF - Growth Factors
SN - 0897-7194
IS - 5-6
ER -