Regulation of germinal center responses, memory B cells and plasma cell formation-an update

Lynn M. Corcoran, David M. Tarlinton

Research output: Contribution to journalReview ArticleOtherpeer-review

69 Citations (Scopus)


Progress in understanding humoral immunity has been accelerated by the powerful experimental approaches of genetics, genomics and imaging. Excellent reviews of these advances appeared in 2015 in celebration of the 50th anniversary of the discovery of B cell and T cell lineages in the chicken. Here we provide a contemporary model of B cell differentiation, highlighting recent publications illuminating germinal center (GC), memory B cell and antibody-secreting plasma cell biology. The important contributions of CD4T cells to antibody responses have been thoroughly reviewed elsewhere.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalCurrent Opinion in Immunology
Publication statusPublished - 1 Apr 2016
Externally publishedYes

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