Regulation of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device applying switching control

Miguel E. Combariza, Xinghuo Yu, Warwick S. Nesbitt, Arnan Mitchell, Francisco J. Tovar-Lopez

Research output: Contribution to conferencePaperOtherpeer-review

Abstract

Arterial thrombosis continues to be a major cause of death in spite of intensive cardiovascular research. Recent discoveries have highlighted the primary role of shear rate microgradients in the aggregation of platelets and thrombus growth. This has prompted the development of in-vitro microfluidic platforms to study the underlying principles relating these variables. These platforms that typically operate in open-loop can be greatly refined through the incorporation of feedback control systems. This paper presents the design of an automatic controller for the regulation of platelet aggregation through modulation of shear rate in a state-of-the-art microfluidic platform. Such a controller is expected to deal with issues such as noise measurement noise, inter and intra-patient variability, and nonlinear behaviours. The controller is based on principles of variable structure systems, sliding mode control (SMC), coupled with a module of pulse-width modulation (PWM) in order to provide a near timeoptimal time response with a smooth switching control action. Simulation results demonstrate the suitability of the controller for the regulation of platelet aggregation in the microfluidic platform of study, and eventually its application on automated diagnosis of shear rate-dependent platelet function.

Original languageEnglish
Pages644-649
Number of pages6
DOIs
Publication statusPublished - 1 Jan 2013
Event2013 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013 - Hangzhou, China
Duration: 16 Dec 201318 Dec 2013

Conference

Conference2013 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013
CountryChina
CityHangzhou
Period16/12/1318/12/13

Cite this

Combariza, M. E., Yu, X., Nesbitt, W. S., Mitchell, A., & Tovar-Lopez, F. J. (2013). Regulation of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device applying switching control. 644-649. Paper presented at 2013 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013, Hangzhou, China. https://doi.org/10.1109/BMEI.2013.6747019
Combariza, Miguel E. ; Yu, Xinghuo ; Nesbitt, Warwick S. ; Mitchell, Arnan ; Tovar-Lopez, Francisco J. / Regulation of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device applying switching control. Paper presented at 2013 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013, Hangzhou, China.6 p.
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Combariza, ME, Yu, X, Nesbitt, WS, Mitchell, A & Tovar-Lopez, FJ 2013, 'Regulation of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device applying switching control' Paper presented at 2013 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013, Hangzhou, China, 16/12/13 - 18/12/13, pp. 644-649. https://doi.org/10.1109/BMEI.2013.6747019

Regulation of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device applying switching control. / Combariza, Miguel E.; Yu, Xinghuo; Nesbitt, Warwick S.; Mitchell, Arnan; Tovar-Lopez, Francisco J.

2013. 644-649 Paper presented at 2013 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013, Hangzhou, China.

Research output: Contribution to conferencePaperOtherpeer-review

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AB - Arterial thrombosis continues to be a major cause of death in spite of intensive cardiovascular research. Recent discoveries have highlighted the primary role of shear rate microgradients in the aggregation of platelets and thrombus growth. This has prompted the development of in-vitro microfluidic platforms to study the underlying principles relating these variables. These platforms that typically operate in open-loop can be greatly refined through the incorporation of feedback control systems. This paper presents the design of an automatic controller for the regulation of platelet aggregation through modulation of shear rate in a state-of-the-art microfluidic platform. Such a controller is expected to deal with issues such as noise measurement noise, inter and intra-patient variability, and nonlinear behaviours. The controller is based on principles of variable structure systems, sliding mode control (SMC), coupled with a module of pulse-width modulation (PWM) in order to provide a near timeoptimal time response with a smooth switching control action. Simulation results demonstrate the suitability of the controller for the regulation of platelet aggregation in the microfluidic platform of study, and eventually its application on automated diagnosis of shear rate-dependent platelet function.

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Combariza ME, Yu X, Nesbitt WS, Mitchell A, Tovar-Lopez FJ. Regulation of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device applying switching control. 2013. Paper presented at 2013 6th International Conference on Biomedical Engineering and Informatics, BMEI 2013, Hangzhou, China. https://doi.org/10.1109/BMEI.2013.6747019