The dramatic changes that male germ cells in the adult testis undergo in gene expression profile and morphology as they transition from spermatogonial stem cells through to mature spermatozoa is dependent upon their association with Sertoli cells. Sertoli cells are crucial for survival and maturation of male germ cells. Two recent papers, Holembowski et al.  and Inoue et al.  have described a surprising role for the p53 family member, p73, in regulation of germ cell-Sertoli cell adhesion.