Regulation of β-adrenoceptors in a rat model of cardiac failure: Effect of perindopril

X. H. Gu, A. R. Kompa, R. J. Summers

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This study investigated the effects of myocardial infarction (MI)- induced cardiac failure and treatment with an angiotensin-converting enzyme (ACE) inhibitor perindopril (2 mg/kg/day) on rat β-adrenoceptor (β-ar) subtypes in anatomically defined regions of infarcted left ventricular (LV) free wall and noninfarcted tissue from right ventricle (RV) by using autoradiography. After 5 weeks of MI, rats with large MI size (>42%) had developed cardiac failure and [β1-ars were significantly decreased (-59%; p < 0.01) in the border region of the infarcted LV and almost abolished in the infarcted area (-90%; p < 0.005) compared with normal LV from sham-operated controls. The β-ar changes were not found in the noninfarcted area of the same LV or in RV. MI did not significantly alter the number of β2-at subtypes in any region of the ventricles. Perindopril treatment for 4 weeks reduced mean cardiac region weights but did not affect β-ar density in any cardiac region in either sham-operated or MI rats. These results indicate that cardiac failure due to MI causes significant downregulation of β1-ars only in border and infarcted regions of rat LV and no change in β2-at in any area. It also suggests that the improved response of the infarcted rat heart to isoprenaline stimulation after ACE inhibitors does not result from changes in the numbers of cardiac β-ars.

Original languageEnglish
Pages (from-to)66-74
Number of pages9
JournalJournal of Cardiovascular Pharmacology
Volume32
Issue number1
DOIs
Publication statusPublished - 1 Jul 1998

Keywords

  • β-Adrenoceptor
  • Angiotensin-converting enzyme inhibition
  • Autoradiography
  • Cardiac failure
  • Myocardial infarction
  • Perindopril

Cite this

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title = "Regulation of β-adrenoceptors in a rat model of cardiac failure: Effect of perindopril",
abstract = "This study investigated the effects of myocardial infarction (MI)- induced cardiac failure and treatment with an angiotensin-converting enzyme (ACE) inhibitor perindopril (2 mg/kg/day) on rat β-adrenoceptor (β-ar) subtypes in anatomically defined regions of infarcted left ventricular (LV) free wall and noninfarcted tissue from right ventricle (RV) by using autoradiography. After 5 weeks of MI, rats with large MI size (>42{\%}) had developed cardiac failure and [β1-ars were significantly decreased (-59{\%}; p < 0.01) in the border region of the infarcted LV and almost abolished in the infarcted area (-90{\%}; p < 0.005) compared with normal LV from sham-operated controls. The β-ar changes were not found in the noninfarcted area of the same LV or in RV. MI did not significantly alter the number of β2-at subtypes in any region of the ventricles. Perindopril treatment for 4 weeks reduced mean cardiac region weights but did not affect β-ar density in any cardiac region in either sham-operated or MI rats. These results indicate that cardiac failure due to MI causes significant downregulation of β1-ars only in border and infarcted regions of rat LV and no change in β2-at in any area. It also suggests that the improved response of the infarcted rat heart to isoprenaline stimulation after ACE inhibitors does not result from changes in the numbers of cardiac β-ars.",
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Regulation of β-adrenoceptors in a rat model of cardiac failure : Effect of perindopril. / Gu, X. H.; Kompa, A. R.; Summers, R. J.

In: Journal of Cardiovascular Pharmacology, Vol. 32, No. 1, 01.07.1998, p. 66-74.

Research output: Contribution to journalArticleResearchpeer-review

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