Abstract
Persistent stomach infection with Helicobacter pylori causes chronic mucosal inflammation (gastritis), which is widely recognized as an essential precursor to gastric cancer. The IL-1 interleukin family cytokines IL-1β and IL-18 have emerged as central mediators of mucosal inflammation. Here, we review the regulation and functions of these cytokines in H. pylori-induced inflammation and carcinogenesis.
Original language | English |
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Pages (from-to) | 449-458 |
Number of pages | 10 |
Journal | Microbes and Infection |
Volume | 19 |
Issue number | 9-10 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Gastric cancer
- Helicobacter pylori
- IL-18
- IL-1β
- Inflammasome
- NOD-like receptors