Regulation and functions of inflammasome-mediated cytokines in Helicobacter pylori infection

Le Son Tran, Michelle Chonwerawong, Richard L. Ferrero

Research output: Contribution to journalReview ArticleResearchpeer-review

28 Citations (Scopus)

Abstract

Persistent stomach infection with Helicobacter pylori causes chronic mucosal inflammation (gastritis), which is widely recognized as an essential precursor to gastric cancer. The IL-1 interleukin family cytokines IL-1β and IL-18 have emerged as central mediators of mucosal inflammation. Here, we review the regulation and functions of these cytokines in H. pylori-induced inflammation and carcinogenesis.

Original languageEnglish
Pages (from-to)449-458
Number of pages10
JournalMicrobes and Infection
Volume19
Issue number9-10
DOIs
Publication statusPublished - 2017

Keywords

  • Gastric cancer
  • Helicobacter pylori
  • IL-18
  • IL-1β
  • Inflammasome
  • NOD-like receptors

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